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ImClone Systems Showcases Extensive Research and Development,Program at the AACR Annual Meeting

NEW YORK--(BUSINESS WIRE)--Apr 19, 2007 - IgG1 monoclonal antibodies developed by ImClone Systems Incorporated (NASDAQ: IMCL) were the focus of 44 total presentations at the recently concluded 98th Annual Meeting of the American Association for Cancer Research (AACR), including seven oral presentations and 37 posters.

Important ERBITUX(R) (cetuximab) clinical data were the focus of two back-to-back oral presentations leading off the "Breakthroughs in Clinical Research" Plenary Session on April 16, 2007, which highlights the most important clinical studies presented at this prestigious meeting. The remaining presentations showcased ImClone's extensive research and development program with results from studies involving both ERBITUX, an IgG1 monoclonal antibody that targets the epidermal growth factor receptor (EGFR), and multiple investigational monoclonal antibodies in the ImClone pipeline that target other critical cancer pathways.

Like ERBITUX, the monoclonal antibodies in the ImClone pipeline are all type 1 immunoglobulin G (IgG1) antibodies. In vitro, IgG1 antibodies elicit antibody-dependent cellular cytotoxicity (ADCC), which can kill cancer cells and may contribute to their overall therapeutic effects. These novel fully human antibodies, many of which are in early phase clinical testing, target cell surface receptors in various signaling pathways known or believed to play important roles in the growth and proliferation of tumors or tumor vasculature. Specific targets include insulin-like growth factor-1 receptor (IGF-1R), vascular endothelial growth factor receptor-1 (VEGFR-1), VEGFR-2, VEGFR-3, platelet-derived growth factor receptor alpha (PDGFR(alpha)), FMS-like tyrosine kinase 3 receptor (FLT3), fibroblast growth factor receptor 3 (FGFR3), among others.

"Our pipeline consists of a robust collection of IgG1 monoclonal antibodies targeted against cellular pathways that are emerging as cri
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