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IR BioSciences Announces Data Demonstrating Radilex Stimulation of,Stem Cells Results in Hematopoietic Recovery Following Lethal,Irradiation

ilex to address both the government market, as a countermeasure to radiological dispersion devices ("dirty bombs"), as well as the cancer market, as an adjuvant treatment candidate potentially ameliorating the side effects resulting from cancer radiotherapy.

"Recognizing our candidate product has this effect is very motivating. These results suggest a myriad of potential applications in which stem cell replenishment is clinically useful, and not just leukemias and lymphomas. We are excited about our research program and while focused on our current development plan, fully expect to broaden our understanding of the potential of Radilex based on upcoming and planned studies at Battelle and TGen" said ImmuneRegen CEO Michael Wilhelm.

Hollis-Eden and Cleveland BioLabs recently reported results on their respective radioprotectants in development. Hollis-Eden reported on the effects of NEUMUNE(R) (HE2100) in non-human primates exposed to 0.6 Gy total body irradiation and without clinical support such as antibiotics, IV fluids and platelet transfusions. They show an increase in survival in monkeys injected daily with NEUMUNE for 5 days despite severe neutropenia and thrombocytopenia. Of particular note, they find the platelet-restoring effect of their steroid to be most predictive of survival in treated animals. Studies carried out by Cleveland BioLabs have revealed the ability of their CBLB502 radioprotectant to protect non-human primates from the hematopoietic (as well as gastrointestinal) damage of gamma radiation. Also, their CBLB612 compound has been reported to increase bone marrow hematopoietic stem cells and enhance mobilization of these cells from bone marrow. They hypothesize that these cells are useful in repopulating irradiated animals with functionally competent hematopoietic components, thus enhancing survival following lethal doses of radiation.

ImmuneRegen has routinely utilized lethal total body radiation doses (7-9 Gy) in previously r
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