Navigation Links
IR BioSciences Announces Data Demonstrating Radilex Stimulation of,Stem Cells Results in Hematopoietic Recovery Following Lethal,Irradiation

Animal Data Shows Prolonged Survival AND Increased Platelet Concentrations

SCOTTSDALE, Ariz., March 08, 2007 /PRNewswire-FirstCall/ -- ImmuneRegen BioSciences, a wholly-owned subsidiary of IR BioSciences Holdings, Inc. announced today that ongoing analysis of data acquired from previously performed animal efficacy studies has revealed evidence that ImmuneRegen's developmental stage product, Radilex(TM), may stimulate hematopoietic stem cells.

Studies performed at the Oak Ridge National Laboratory reveal that ImmuneRegen's potential radioprotectant product, Radilex, not only prolonged survival of animals exposed to lethal gamma irradiation, but appeared to have increased platelet concentrations in surviving animals. As the experimental protocol required these animals to be subject to repeated blood sampling as well as irradiation, saline injections were relied on for plasma volume restoration. In the face of the resulting hemodilution, compensatory hematopoietic mechanisms were nonetheless adequately stimulated to enable survival of a number of Radilex-treated, but no untreated, animals. Blood cell quantitation showed trends in the surviving animals toward neutrophil replenishment as well. ImmuneRegen has since filed a provisional patent entitled "Method to Treat Blood Cell Depletion" to provide intellectual property protection for this finding regarding Radilex.

Continuing radiation studies will be performed at both the Translational Genomics Research Institute (TGen) and TGen Drug Development Services (TD2, its drug development arm) and at the Pacific Northwest National Laboratory to further explore the impact of radiation on the hematopoietic system of Radilex-exposed animals. ImmuneRegen's ongoing studies will be designed to examine mechanistic indicators at both high levels of radiation where Radilex has shown protection, as well as at lower levels. If successful, these studies will enable Rad ilex to address both the government market, as a countermeasure to radiological dispersion devices ("dirty bombs"), as well as the cancer market, as an adjuvant treatment candidate potentially ameliorating the side effects resulting from cancer radiotherapy.

"Recognizing our candidate product has this effect is very motivating. These results suggest a myriad of potential applications in which stem cell replenishment is clinically useful, and not just leukemias and lymphomas. We are excited about our research program and while focused on our current development plan, fully expect to broaden our understanding of the potential of Radilex based on upcoming and planned studies at Battelle and TGen" said ImmuneRegen CEO Michael Wilhelm.

Hollis-Eden and Cleveland BioLabs recently reported results on their respective radioprotectants in development. Hollis-Eden reported on the effects of NEUMUNE(R) (HE2100) in non-human primates exposed to 0.6 Gy total body irradiation and without clinical support such as antibiotics, IV fluids and platelet transfusions. They show an increase in survival in monkeys injected daily with NEUMUNE for 5 days despite severe neutropenia and thrombocytopenia. Of particular note, they find the platelet-restoring effect of their steroid to be most predictive of survival in treated animals. Studies carried out by Cleveland BioLabs have revealed the ability of their CBLB502 radioprotectant to protect non-human primates from the hematopoietic (as well as gastrointestinal) damage of gamma radiation. Also, their CBLB612 compound has been reported to increase bone marrow hematopoietic stem cells and enhance mobilization of these cells from bone marrow. They hypothesize that these cells are useful in repopulating irradiated animals with functionally competent hematopoietic components, thus enhancing survival following lethal doses of radiation.

ImmuneRegen has routinely utilized lethal total body radiation doses (7-9 Gy) in previously r eported animal studies of Radilex and has never artificially accelerated morbidity, or provided clinical support, to post- radiation post-Radilex animals. Thus, these future studies at TD2 and Pacific Northwest National Laboratory have the potential to accelerate ImmuneRegen's Radilex development program, and may support Radilex evaluation in non-human primates later this year while advancing the understanding of the underlying mechanisms by which its radioprotectant activity is achieved.

About Radilex(TM) and Viprovex(TM)

Radilex(TM) is the trade name used in referring to formulations of Homspera(TM) for potential indications for treatment of exposure to ionizing radiation. Viprovex(TM) is the trade name used in referring to formulations of Homspera for potential indications for treatment of viral and bacterial infections. Homspera is a generic name used by the Company to describe the synthetic peptide Sar9, Met (O2)11-Substance P, an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species. All of the Company's research and development efforts are early, pre-clinical stage and Homspera, as Viprovex(TM) and Radilex(TM), has only undergone exploratory studies to evaluate its biological activity in small animals.

About ImmuneRegen BioSciences, Inc.

IR BioSciences Holdings, Inc., through its wholly owned subsidiary ImmuneRegen BioSciences, Inc., is a development stage biotechnology company focused on the research and development of Homspera(TM) and its derivatives Radilex(TM) and Viprovex(TM), which are designed to be used as countermeasures for multiple homeland security bioterrorism threats. Homspera is derived from Substance P, a naturally occurring peptide immunomodulator and homeostatic compound with the dual effect of improving pulmonary function and the stimulation of the human immune system. For more information, please visit t he company's website at

Statements about the Company's future expectations, including statements about the potential for the Company's drug candidates, science and technology, and all other statements in this press release other than historical facts, are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934, and as that term is defined in the Private Securities Litigation Reform Act of 1995. The Company intends that such forward-looking statements be subject to the safe harbors created thereby. These future events may not occur as and when expected, if at all, and, together with the Company's business, are subject to various risks and uncertainties. The Company's actual results could differ materially from expected results as a result of a number of factors, including the fact that preliminary results involved only a small number of test mice, the subsequent investigations were limited in scope, the uncertainties inherent in research and development collaborations, pre- clinical and clinical trials and product development programs, (including, but not limited to the fact that future results or research and development efforts may prove less encouraging than current results or cause side effects not observed in current pre-clinical trials) the evaluation of potential opportunities, the level of corporate expenditures and monies available for further studies, capital market conditions, and others set forth in the Company's periodic report on Form 10-QSB for the three months ended September 30, 2006 and on Form 10-KSB for the twelve months ended December 31, 2005 as filed with the Securities and Exchange Commission. There are no guarantees that any of the Company's proposed products will prove to be commercially successful. The Company undertakes no duty to update forward-looking statements.< /p>



    W. Jason Grimley

    Spelling Communications




    Josh Reynolds

    CEOcast, Inc.




    Bill Lane

    ImmuneRegen BioSciences, Inc.


CONTACT: Media, W. Jason Grimley of Spelling Communications,+1-310-477-9500, , for IR BioSciences Holdings, Inc.;or Investors, Josh Reynolds of CEOcast, Inc., +1-212-732-4300,; or In-House Investor Contact, Bill Lane ofImmuneRegen BioSciences, Inc., +1-480-922-3926,

Ticker Symbol: (NASDAQ-OTCBB:IRBO)

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


Related medicine technology :

1. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
2. YM BioSciences Announces Preclinical Data Confirming Nimotuzumab Binds to the EGF Receptor and Potentiates Radiotherapy
3. Sangamo BioSciences Announces Presentation of Phase 1 ZFP Therapeutic Data at American Diabetes Association Meeting
4. IR BioSciences Announces Promising Data from Study of Its Compound Homspera
5. Sangamo BioSciences Announces Presentation of ZFP Therapeutic Data From Nerve Regeneration Program at American Society for Neural Therapy and Repair Meeting
6. YM BioSciences Reports AeroLEF Randomized Phase IIb Trial Meets Primary Endpoint in Patients with Post-Surgical Pain
7. ImmuneRegen BioSciences Announces Promising Data on Homspera Suggesting Potential as a Co-Therapeutic Agent
8. Study in Cell by Magen BioSciences Co-Founder David E. Fisher Identifies New Roles in Skin Cancer Prevention for Key Tumor Suppressor Protein
9. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
10. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
11. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
Post Your Comments:
(Date:11/25/2015)... , Nov. 25, 2015  Linden Care, LLC, ... optimizing treatment outcomes for patients suffering from chronic pain, ... for a Temporary Restraining Order (TRO) enjoining Express Scripts ... two companies. --> --> ... all of its legal options. --> ...
(Date:11/25/2015)... AVIV, Israel , November 25, 2015 ... (NASDAQ: KTOV ) (TASE: KTOV), a biopharmaceutical company ... simultaneous treatment of various clinical conditions, today announced the ... 3,158,900 American Depository Shares ( ADSs ), each representing ... purchase up to 3,158,900 ADSs. The ADSs and warrants ...
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 Endo International ... Rajiv De Silva , President and CEO, will discuss ... Healthcare Conference in New York on ... . Click on Investor Relations, and then the ... prior to the presentation,s start time to visit the site ...
Breaking Medicine Technology:
(Date:11/25/2015)... ... November 25, 2015 , ... Beddit® has launched a new Android app ... new app features a more intuitive SleepScore™ that rates sleep quality on a 100-point ... SleepScore is created by a proprietary algorithm. Beddit analyzes the data to provide an ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical ... Center (RMC) in Chicago, IL, UV Angel is evaluating the efficacy of its product ... intensive care units (totaling 30 beds) from May 2014 through October 2015 at a ...
(Date:11/25/2015)... ... , ... Today, Mothers Against Drunk Driving (MADD) learned that the ... the first time since 2011. In 2014, there were 9,967 fatalities involving an alcohol ... National Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic crashes in ...
(Date:11/25/2015)... ... November 25, 2015 , ... In ... nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care for pulmonary hypertension ... Pioneers, nominated by the public, will receive special recognition throughout 2016 as part ...
(Date:11/25/2015)... ... November 25, 2015 , ... Privately owned Contract Development ... expansion of its current state of the art research, development and manufacturing facility ... increase its manufacturing capacity as well as to support its clients’ growing research ...
Breaking Medicine News(10 mins):