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Human Genome Sciences Reports That a Phase 2 Study of LymphoStat-B,Showed Significant Reductions in Disease Activity in Patients with,Active Systemic Lupus Erythematosus

o Week 76 in B-cell subsets including total CD20+, naive (CD20+/CD27-), activated (CD20+/CD69+), and plasmacytoid (CD20+/CD138+). -- An increase in C4 complement among patients with low C4 complement at baseline (33% at Week 52; 46% at Week 76). -- Stable reductions in immunoglobulins, with no increase in infections or infectious events over time.

In addition, the 52-Week data showed that, in serologically active SLE patients, LymphoStat-B:

    -- Significantly delayed the time to SLE flare after six months (p<0.04);


    -- Significantly reduced the frequency of patients transitioning from low-

       dose prednisone (<7.5 mg/day) to high-dose prednisone (>7.5 mg/day)

       (p<0.05 over multiple time-points);


    -- Significantly reduced the number of patients experiencing BILAG

       Neurological and Musculoskeletal organ domain flares at Week 52

       (Neurological p=0.04; Musculoskeletal p<0.01); Cardiovascular-

       Respiratory (p=0.06); and


    -- Produced significant and clinically meaningful improvements in health-

       related quality of life.

About LymphoStat-B

LymphoStat-B is a human monoclonal antibody that specifically recognizes and inhibits the biological activity of B-lymphocyte stimulator, or BLyS(R). BLyS is a naturally occurring protein discovered by HGS that is required for the development of B-lymphocyte cells into mature plasma B cells. Plasma B cells produce antibodies, the body's first line of defense against infection.

In lupus, rheumatoid arthritis and certain other autoimmune diseases, elevated levels of BLyS are believed to contribute to the production of autoantibodies -- antibodies that attack and destroy the body's own healthy tissues. The presence of autoantibodies appears to correlate with disease severity. Pre-clinical and clinical studies demonstrate that B-cell antagonists can reduce autoantibody levels and help control autoi
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