( gle agentin advanced non-small cell lu...)Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers,Health

gle agent in advanced non-small cell lung cancer, colorectal cancer and non-Hodgkin's lymphoma. It was demonstrated that HGS-ETR1 has single-agent antitumor activity (complete and partial responses) in non-Hodgkin's follicular B-cell lymphoma. The Company is also conducting Phase 1b studies of HGS-ETR1 in combination with chemotherapy.

An accompanying editorial in JCO commented that, "The main goals ahead with these agents will be increasing our understanding of the biologic mechanisms underlying tumor response versus resistance, pursuing logical combinations that counter these resistant mechanisms, and considering appropriate patient selection to enrich for a responsive population."

Presentations at AACR 2007

At the Annual Meeting of the American Association of Cancer Research last week, Robin C. Humphrey, Ph.D., Senior Scientist and preclinical lead, HGS oncology research, presented an overview of preclinical and clinical studies to date for both of the HGS TRAIL receptor antibodies. Results to date show that HGS-ETR1 and HGS-ETR2 specifically bind to TRAIL receptor 1 or TRAIL receptor 2, respectively, and directly induce programmed cell death, or apoptosis, in a broad array of cancer cell lines and primary cancer cells derived from both solid and hematologic human tumors. Results of studies in tumor cell xenografts demonstrate that HGS-ETR1 and HGS-ETR2 cause significant inhibition of tumor growth, including rapid tumor regression in a number of models. Studies have also shown that both of the HGS TRAIL receptor antibodies are active in combination with a spectrum of conventional or novel therapeutic agents, including chemotherapy, radiation and proteosome inhibitors. Both HGS-ETR1 and HGS-ETR2 are currently being evaluated in clinical trials in a variety of human tumors.

In a separate poster presentation, results were reported from a preclinical study, which demonstrated that low concentrations of Velcade (bortezomib) can be used to s
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