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Human Genome Sciences Announces Positive Final Results Of Phase 2b,Trial of Albuferon

es than the Pegasys treatment group. Among heavier patients (>75 kg) who were treatment-adherent, 71.2% of those in the combined groups receiving Albuferon every two weeks achieved SVR, versus 53.3% for patients receiving Pegasys once a week. The ability to maintain efficacy in heavier patients is of particular importance in certain markets, including the United States, where a large percentage of patients weigh more than 75 kg.

Top-Line Final Results by Treatment Group

The top-line final results of the Phase 2b trial at Week 24 following the completion of therapy include the following SVR rates and other findings:

    Albuferon 900-mcg Every Two Weeks (Albuferon 900 Q2w)


    -- Based on an intention-to-treat (ITT) analysis, 58.5% of patients in the

       Albuferon 900 Q2w treatment group achieved SVR, vs. 57.9% for Pegasys

       administered every week.

    -- In heavier patients (>75 kg) who were treatment-adherent, 74.2% of

       those in the Albuferon 900 Q2w treatment group achieved SVR, versus

       53.3% for Pegasys.

    -- Among all treatment-adherent patients in the Albuferon 900 Q2w

       treatment group, 72.3% achieved SVR, versus 66.7% for Pegasys.

    -- Based on the SF-36 Health Survey, patients in the Albuferon 900 Q2w

       treatment group reported less impairment of health-related quality of

       life, compared with patients in the Pegasys treatment group, as

       measured by both physical component and mental component SF-36 summary

       measures at all time-points throughout the 48-week treatment period.

    -- Fewer working patients in the Albuferon 900 Q2w treatment group

       reported missing 7 days or more of work during the month prior to their

       visits at Weeks 12 and 24, vs. the Pegasys group (Week 12:  3.0% for

       Albuferon 900 Q2w vs. 19.2% for Pegasys; Week 24:  5.8% for Albuferon

       900 Q2w, vs. 22.4% for Pegasys).

    -- The rate of discontinuations due to adverse e
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