Recently, HepaLife's PICM-19 liver cell line for use in an artificial liver device significantly outperformed the world's most widely used human liver cell line, the HepG2-C3A. In tests designed to measure a crucial function of the liver, HepaLife's PICM-19 cells successfully synthesized 100% of the ammonia present, almost four times more than HepG2-C3A.
The same tests also demonstrated that PICM-19 cells are able to express high levels of cytochrome P-450 enzymes, a key liver-related function in the detoxification of drugs and xenobiotics. In contrast, HepG2-C3A showed very low or no detectable P450 activity at all.
(View HepaLife's April 10, 2007 press release and photographs: PICM-19 cells mimic liver's responses; significantly outperform most widely-used liver cell line: http://www.hepalife.com/20070410-1.html.php)
In previous weeks, HepaLife's proprietary bioreactor system, the main mechanical component of its patented bioartificial liver device, successfully replicated the liver's key function -- removal of toxic ammonia and synthesis of urea. Researchers consider this ability vital to successfully replicating the human liver's function in an artificial liver device.
(View HepaLife's April 30, 2007 press release: HepaLife achieves major milestone in development of artificial liver device: http://www.hepalife.com/20070430-1.html.php)
ABOUT HEPALIFE TECHNOLOGIES, INC.
HepaLife Technologies, Inc. (OTCBB: HPLF - News; FWB: HL1) (WKN: 500625) is a biotechnology company focused on the identification and development of cell-based technologies and products.
Current cell-based technologies under development by HepaLife
include 1) the first-of-its-kind artificial liver device, 2)
proprietary in-vitro toxicology and pre-clinical drug testing
platforms, and 3) novel cell-culture based vaccine production to
protect against t