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Hemispherx Presents Evidence of Ampligen Synergies with Existing,Antivirals at International Avian Influenza Conference

PARIS--(BUSINESS WIRE)--Jun 4, 2007 - Hemispherx Biopharma, Inc. (AMEX: HEB), a biopharmaceutical company engaged in the clinical development of new drug entities for the treatment of pandemic disease threats, announced today a new scientific report on the activity of its experimental therapeutic Ampligen(R) in combination with approved anti-influenza agents against highly pathogenic avian influenza (HPAI), also known as bird flu.

Tamiflu resistance by newly emerging strains of HPAI has been widely reported (New Engl. Journal Medicine vol. 353: page 2667, 2005) and has provided impetus for new ways to implement an antiviral counter-attack strategy.

In in vitro studies, Ampligen(R), an experimental therapeutic, was combined with the neuraminidase inhibitors Oseltamivir, (brand name Tamiflu) and with Zanamivir (Relenza) and thereafter applied to cells in culture infected with an H5N1 strain of HPAI. Three days following infection, cell viability and synergy analyses were performed.

Both Ampligen(R) and the neuraminidase inhibitors exhibited dose responses in the inhibition of the adverse effects of HPAI on cell cultures. Moreover, the combination of Ampligen(R) with oseltamivir at doses exceeding a certain threshold showed synergistic inhibition of viral induced cell destruction, and similar synergistic results were seen with the combination of Ampligen(R) with zanamivir.

The study results are being presented at the ongoing 2nd International Conference on Avian Influenza, being held at the Pasteur Institute.

While it is widely recognized that HPAI is a major, global public health concern, existing antiviral monotherapies can rapidly lead to drug-resistant strains of virus. Therefore, the Hemispherx study was conducted to establish a potentially pivotal role for Ampligen as part of a potentially effective combination therapy. Ampligen(R) is a novel double-stranded RNA experimental thera
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