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Hana Biosciences Presents Data On Two Programs At the American,Society of Clinical Oncology Annual Meeting

effect of erlotinib. In contrast, researchers found that steroids and immunosuppressive agents may potentiate the cytotoxic effect of anti-EGFR inhibitors in the skin, thus providing a possible explanation for the erratic and mixed therapeutic results often observed with the use of these agents. This data was presented by Roman Perez-Soler, M.D., Chief of the Division of Oncology in the Department of Medicine at the Albert Einstein College of Medicine in New York in an abstract titled "Steroids and immunosuppressive agents potentiate the cytotoxicity of the EGFR inhibitor erlotinib (E) in human skin keratinocytes whereas Menadione (Vit K3) exerts a protective effect: implications for the management of the skin rash" (#9124).

Results from a Phase I, single-center, open-label, randomized, 2-arm crossover study of Marqibo in Stage III or IV melanoma patients were presented in an abstract titled "A pharmacokinetic comparison of the Marqibo 3- and 5- vial injection kits in metatastic melanoma patients" (#8575) by members of the study team lead by Dr. Agop Bedikian of the UT MD Anderson Cancer Center in Houston. The study showed that the 3- and 5- vial kits produced a bioequivalent pharmacokinetic (PK) profile. Single agent Marqibo was also generally well tolerated in metastatic melanoma patients with an adverse event profile similar to conventional vincristine. In addition, Marqibo showed promising single agent activity against Stage IV metastatic melanoma. Hana is currently developing Marqibo for use in the treatment of patients with acute lymphoblastic leukemia.

About Menadione

Menadione, a small organic molecule, has been shown to activate the Epidermal Growth Factor Receptor (EGFR) signaling pathway by inhibiting phosphatase activity. EGFR inhibitors or EGFRIs are currently used to treat non-small cell lung cancer, pancreatic, colorectal, and head & neck cancer. Approximately seventy-five percent of patients taking EGFRIs develop an associat
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