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Halozyme Therapeutics' Enhanze Technology Large Protein Molecule,Therapeutic Clinical Trial Results Presented at the 34th Annual,Meeting of the Controlled Release Society

hyaluronidase as an adjuvant to increase the absorption and dispersion of co-injected small molecule drugs, to Halozyme's knowledge, this was the first clinical trial conducted to support the benefits and safety of rHuPH20 for use with large molecule agents, such as monoclonal antibodies and other large molecule biologics. Most therapeutic antibodies are 60% to 70% systemically bioavailable following SC injection, allowing room for improvement in absorption. Other therapeutic large molecule agents have even lower systemic bioavailability, and still other agents may not be developed for SC administration because of low systemic bioavailability through this route of administration. rHuPH20 is the first and only hyaluronidase from a recombinant human source that is FDA-approved, currently in a 150 U product configuration.

"The remarkable findings from this clinical trial, estimating that co-injection of rHuPH20 in high doses can boost the SC absolute bioavailability of an LPMT from 64% to essentially 100%, validates similar findings from animal models," said Richard C. Yocum, MD, Vice President of Clinical Development and Medical Affairs at Halozyme. "We have shown previously in two different animal species and with three different representative large molecules that rHuPH20 locally co-injected with the large molecule increases the bioavailability in a rHuPH20 dose-dependent fashion and to essentially complete absorption."

About Halozyme Therapeutics, Inc.

Halozyme is a biopharmaceutical company developing and commercializing recombinant human enzymes for the drug delivery, palliative care, oncology, and infertility markets. The company's portfolio of products is based on intellectual property covering the family of human enzymes known as hyaluronidases. The company's Enhanze(TM) Technology is a novel drug delivery platform designed to increase the absorption and dispersion of biologics. In addition, the company has received FDA approval for two pr
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