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Haemacure Announces Preliminary Findings of its Plasma Discard,Analysis

sma-derived protein market is estimated to reach US$8.5 billion by 2010. The North American market was estimated at US$2.4 billion in 2006. Immunoglobulin is the biggest selling protein in North America, with sales estimated at US$1.4 billion in 2006 in the United States alone. Immunoglobulin is used to treat immunological, neurological and other disorders. Plasminogen, once converted into plasmin, is a clot buster and offers a natural alternative to synthesized solutions to address an unmet need of the market. A1PI is used by patients suffering from hereditary emphysema resulting from A1PI deficiency. A1PI deficiency affects between 60,000 to 100,000 people in the United States.

According to Cowen and Company, enzyme replacement therapies (ERTs) will reach US$3.1B in 2011. ERTs are the cornerstone of treatment of many orphan disorders, particularly the lysosomal storage diseases. Orphan diseases are comprised of number different conditions that each afflict only a small number of individuals, but together constitute one of the most lucrative therapeutic areas. The four leading lysosomal disorder products are intended to treat Gaucher's disease, Fabry's disease, Hurler's disease and Pompe's disease.

In 2006, estimated sales for these four leading lysosomal disorder products were US$1 billion, US$359 million, US$96 million and US$30 million respectively, nearly US$1.5 billion in total. Haemacure has identified in its plasma discard enzymes each treating one of these diseases. The enzymes are alpha-galactosidase, used to treat Fabry's disease, alpha-glucosidase, used to treat Pompe's disease, beta-glucosidase, used to treat Gaucher's disease, and alpha-iduronidase, used to treat Hurler's disease.

Haemacure has also identified three other enzymes, used to treat Hunter's disease, Morquio's disease and Shindler's disease. Products are also in development for these diseases.

As advised, these findings are preliminary and the full value of these
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