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Global Rabies Treatment May be Possible with NanoViricides Drugs

WEST HAVEN, Conn.--(BUSINESS WIRE)--May 14, 2007 - NanoViricides, Inc. (Pink Sheets: NNVC) discussed today the results of recent animal studies against rabies that were presented along with the successful BSL3 in vitro studies against a Clade 2 H5N1 virus at the 23rd Annual Symposium of the Pan American Society for Clinical Virology in Tampa, FL, on Wednesday, May 2. (Pan American Society for Clinical Virology (PASCV): Clinical Virology Symposium)

The animal studies against rabies were conducted in Vietnam using the Challenge Standard Virus strain at a highly lethal infection level of 1,000 LD50 given directly into the brain. NanoViricides drugs based on the broad-spectrum chemicals ligand class, rabies-specific receptor peptide ligand class, as well as rabies-antibody-derived ligand class were tested in both direct intracerebral treatment as well as intraperitoneal treatment modalities. Human anti-Rabies Immunoglobulin (RIG), a commercial standard rabies treatment, was used as positive control.

A 30% survival rate with two of the nanoviricides and 20% survival rate with another two nanoviricides was found in mice treated intracerebrally, Additionally, a 20% survival rate was found with two of these four nanoviricides even on intraperitoneal treatment. All mice treated with RIG died. All of the nanoviricide drug candidates showed efficacy superior to the RIG standard, as measured by various end-points including survival and body-weight.

RIG together with rabies vaccine are given as post-exposure prophylaxis (PEP) in developed countries. However, once clinical signs are evident (prodrome phase), rabies is 100% fatal in humans. Rabies is a very important disease in developing nations. More than 50 cases of rabies infection occur in the US annually. RIG is too expensive to be used in most patients in developing nations. The Company believes that the chemical ligand-based nanoviricides can be made ine
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