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Gilead Announces Presentation of Long-Term Data for Ambrisentan, a,Potential Treatment for Patients With Pulmonary Arterial,Hypertension

mbrisentan during the 12-week primary endpoint period. Of the 36 patients evaluated, two patients discontinued due to adverse events not related to liver toxicity. As of October 2006 (mean exposure = 1.1 years, maximum duration 1.4 years), one patient had developed a transient liver function abnormality that was greater than three times the upper limit of normal and this patient continued receiving treatment with ambrisentan. The long-term adverse event profile appeared similar to results from previous ambrisentan clinical studies and included peripheral edema, headache, dyspnea and flushing.

"Endothelin receptor antagonism has well-established clinical benefits in patients with PAH, but liver toxicity, which frequently leads to discontinuation of treatment, has limited the usefulness of these drugs in some patients," said Dr. McGoon. "The results of this study support the potential of ambrisentan in newly diagnosed patients with PAH, as well as patients who have failed other ERA therapies due to liver function abnormalities."

"PAH is a chronic disease and, as such, we recognize the importance of evaluating the long-term efficacy and safety profile of ambrisentan," said Michael J. Gerber, MD, Senior Vice President, Clinical Research at Gilead. "We will continue to work with the clinical investigators and follow patients from each of these studies so we can better understand the benefits and risks of ambrisentan with long-term treatment."

In addition to these long-term ambrisentan data presentations, two posters describing an integrated analysis of 12-week ARIES-1 and ARIES-2 data are also being presented at ATS. The first poster (Abstract #3192) titled "Ambrisentan Therapy for Pulmonary Arterial Hypertension: An Integrated Analysis of the ARIES-1 and ARIES-2 Studies" was presented today by Nazzareno Galie, MD, Professor of Cardiology at the University of Bologna in Bologna, Italy. The second poster (Abstract #2873) titled "Ambrisentan Improves E
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