Navigation Links
Genzyme Announces Results of Clinical Trials Investigating Powder,Form of Sevelamer Carbonate

CAMBRIDGE, Mass., June 18, 2007 /PRNewswire-FirstCall/ -- Genzyme Corp. today announced the results of two new studies comparing a powder form of Renvela (sevelamer carbonate) to Renagel tablets (sevelamer hydrochloride), including one trial in which patients received the powder form three times per day, and one in which it was administered once per day.

Genzyme is developing Renvela in powder form to provide an additional option for patients with chronic kidney disease in managing their phosphate levels. A New Drug Application for Renvela tablets is already on file with the FDA, and previous studies have shown that the tablet formulation provides equivalent phosphate control to Renagel in patients on dialysis and significant phosphorus control in patients with chronic kidney disease who are not on dialysis. Today's results are the first from trials comparing the efficacy of the powder form of Renvela to Renagel tablets.

In the first powder trial, patients treated with the powder form of Renvela three times per day experienced equivalent phosphorus control to patients treated with Renagel tablets three times per day. As a result, this trial successfully met its primary endpoint.

In the second trial, patients dosed with the powder form of Renvela once per day and those treated with Renagel tablets three times per day achieved statistically significant reductions in serum phosphorus, with both groups reaching target levels for phosphorus control outlined in the K/DOQI treatment guidelines. Phosphorus levels in the Renagel arm (4.6 mg/dL) were lower than those in the Renvela arm (5.3 mg/dL), and this trial did not achieve its primary endpoint of demonstrating non-inferiority of Renvela powder dosed once per day to Renagel tablets dosed three times per day.

In both trials, the safety profile of Renvela was consistent with the previous clinical experience of patients on dialysis using Ren
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
2. Genzyme Announces Results of Clinical Trial of Hylastan
3. Genzyme Announces Results of Clinical Trials Investigating Powder Form of Sevelamer Carbonate
4. Genzyme and Bayer HealthCare Announce Detailed Interim Two-Year Alemtuzumab in Multiple Sclerosis Data Presented at AAN
5. Genzyme Announces Successful Completion of Study Investigating Sevelamer Carbonate in Patients With Chronic Kidney Disease
6. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
7. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
9. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
10. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
11. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
Post Your Comments:
(Date:10/17/2014)... -- UBM Medica US announces that Endocrinology Network , ... who treat patients with type 2 diabetes ... insulin .  Nearly all patients with ... – daily injections of one or more insulin formulations—to ... of pancreatic beta cells. Insulin is a very effective ...
(Date:10/17/2014)...   ndd Medical Technologies , a leader in ... technology, announced that its EasyOne Pro® is now being ... a 140,000 square foot, 44-bed hospital with many outpatient ... serves a large number of Native Americans from several ... and beyond. A portion of its funding comes from ...
(Date:10/17/2014)... People often ask for real world CRT case ... this is that big pharma companies aren,t always willing to ... this together was therefore no easy task, but we are ... companies to put pen to paper and divulge the ins ... caveat - some have asked us to remain anonymous so ...
Breaking Medicine Technology:Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3EasyOne Pro Mobile Respiratory Testing from ndd Medical Technologies Chosen by Choctaw Nation 2Pharma Cool Chain & CRT Benchmarking Report 2
... recent studies,suggest that over-consumption of fluoride can raise ... and the thyroid gland," reports,Scientific American editors (January ... shift," writes author Dan Fagin., "Fluoride, the ... added to,2/3 of public water supplies theoretically to ...
... Dec. 21 A new brain imaging,study by researchers ... shows that cigarette cravings in smokers who are deprived ... of the,brain. Using a novel method of measuring brain ... Neurology at Penn, this study is the,first to show ...
Cached Medicine Technology:'Second Thoughts about Fluoride,' Reports Scientific American 2'Brain Signature' for Cigarette Cravings Identified 2'Brain Signature' for Cigarette Cravings Identified 3
(Date:10/18/2014)... 2014 The famous review site Top10BestSEOHosting.com ... evaluating many web host suppliers carefully, today it announces ... Hosting suppliers in the first half of 2014. ... market. Its internet hosting package helps business companies and ... cost. As a top rated hosting provider, it insists ...
(Date:10/18/2014)... 19, 2014 The excellent ... Hostgator ( http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts ), JustHost and FatCow ... 2014. , “There are thousands of ... good suppliers are not too many. We ... are the most outstanding suppliers when it ...
(Date:10/18/2014)... Operators in the Carpet Cleaning ... cleaning services, such as steam cleaning, dry-cleaning and ... one to two years. According to IBISWorld industry ... during the peak of the global financial crisis, ... cleaning.” The upward trend in household discretionary income ...
(Date:10/18/2014)... 18, 2014 Market Research ... Industry, 2009-2019 is a professional and in-depth ... Chondroitin sulfate industry. The report firstly reviews ... its classification, application and manufacturing technology. The ... manufacturers of Chondroitin sulfate listing their product ...
(Date:10/18/2014)... (HealthDay News) -- Even determined dieters can fail if ... nearby, researchers say. Their new study included 240 ... (a combination of risk factors that increase the risk ... told by their doctors to make lifestyle changes, including ... were involved in a clinical trial comparing two dietary ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com: HostMonster, GreenGeeks And FatCow Are The Best PHP Hosting Suppliers In The First Half Of 2014 2Health News:Top10BestSEOHosting.com: Best Reseller Hosting Companies Announced 2Health News:Carpet Cleaning Services in Australia Industry Market Research Report Now Available from IBISWorld 2Health News:Carpet Cleaning Services in Australia Industry Market Research Report Now Available from IBISWorld 3Health News:Chondroitin Sulfate Industry Global & Chinese Forecast to 2019 Now Available at RnRMarketResearch.com 2Health News:Chondroitin Sulfate Industry Global & Chinese Forecast to 2019 Now Available at RnRMarketResearch.com 3Health News:Chondroitin Sulfate Industry Global & Chinese Forecast to 2019 Now Available at RnRMarketResearch.com 4Health News:Dieters May Be Thwarted by Absence of Healthy Foods 2
... awarded a 63-year-old doctor of Indian origin a four-year ... patients over a 13-year //period between September 1991 and ... qualified in India, moved to Britain in 1973. He ... His one-man practice had 2,900 patients. He began his ...
... water filtration technique which is used to clean up agricultural ... an algae found in lakes and rivers. Engineers are extremely ... method, with a 95% success rate of removal of the ... country already use the technique, which couples activated carbon with ...
... 2,000 people are being recruited from Orkney, Scotland as a ... genes that cause osteoporosis. //The study is to be funded ... and Shapinsay, as well as those from the west of ... The study may cost ?240,000 over the next three years. ...
... (AMARRG), Dr David Rivett, said today that this week's announcement ... Medical Infrastructure Fund (RMIF) was a welcome piece of rare ... RMIF is designed to attract GPs to work in country ... scheme shows that the Government is getting serious about regional ...
... improve quality of care, say researchers in this ... recently recommended //certification of doctors to strengthen professional ... in the United States that allows doctors to ... standards required for licensing purposes. Certified status must ...
... been identified by Howard Hughes Medical Institute researcher Charles S. ... Health after seven years of working together to identify the ... tastes humans can sense -- sweet, bitter, and umami. ... primary gateway in all mammals for the detection of spoiled ...
Cached Medicine News:Health News:Indian Doctor in Britain Jailed for Molesting Patients 2Health News:Fresh Water Algae Filtered Out With Water Filtration Technique 2Health News:Fresh Water Algae Filtered Out With Water Filtration Technique 3Health News:New Study To Identify Osteoporosis Genes 2Health News:RMIF Boost a Boon for Rural Health 2Health News:Certification of UK Doctors Would Improve Quality of Care 2Health News:Sour Taste Sensors Identified 2Health News:Sour Taste Sensors Identified 3
... physicians looking for a traditional ... communications with electronic storage features, ... best of both worlds. It ... features of the Atria 3000 ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: