Navigation Links
Gentium's Defibrotide Highlighted in Two Poster Presentations at,American Association for Cancer Research Annual Meeting

ase gene expression, but also decreases its enzymatic activity in MM cell lines. Thus, Defibrotide may suppress tumor-associated angiogenesis and tumor dissemination through suppression of heparanase with a subsequent reduction in the release of stores of growth factors from the extra-cellular matrix. This, in part, may explain Defibrotide's anti-MM activity both in vitro and in vivo."

On Tuesday, April 17, 2007, from 1:00 p.m. to 5:00 p.m. (Pacific Time), Dr. Gunther Eissner, Ph.D., Gentium's Chief of Biology, will present a poster entitled "Defibrotide: an endothelium stabilizing drug prevents angiogenesis in vitro and in vivo." (Poster session 21, Tumor Biology 29, Abstract #4627, Board #30)

The anti-angiogenic potential of Defibrotide was tested in vitro using a kit with human micro-vascular endothelial cells forming vessel structures across a layer of dermal fibroblasts. The results demonstrated that Defibrotide at concentrations corresponding to pharmacological Defibrotide blood levels (100 (mu)g/mL) reduced vessel formation, which could be confirmed by two classical in vitro angiogenesis assays (tube formation in matrigel, rat aortic ring sprouting).

In vivo, tumor angiogenesis was assessed in the murine dorsal skin-fold chamber model using the inoculation of human gastric adenocarcinoma (TMK-1) cells. Intravenous application of Defibrotide (450 mg/kg daily) significantly reduced tumor angiogenesis, as measured by micro-vascular density at day 7 (p=0.035).

The signal transduction mechanism of Defibrotide as demonstrated by Western blotting results show that Defibrotide reduces phosphorylation-activation of p70S6 kinase, which is a key target in the PI3K/Akt/mTOR signaling pathway linked to angiogenesis. Additional in vitro data show that Defibrotide does not influence proliferation of vascular, perivascular or tumor cells, and that it might selectively act through a migration and tube formation inhibition of endothelial cells.


'"/>




Page: 1 2 3 4

Related medicine technology :

1. Gentiums Defibrotide Seen as Active in Multiple Myeloma
2. Gentiums Defibrotide Highlighted in Poster Presentation at World Congress of Nephrology
3. Positive Results for Second-Generation Taxus Liberte Coronary Stent System Highlighted in Journal of American College of Cardiology
4. Isotechnikas Lead Drug, ISA247, To Be Highlighted at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
5. Aeolus Pharmaceuticals AEOL 10150 Highlighted in Nature Genetics Publication
6. Alfacells Onconase Highlighted in Latest Edition of Handbook of Therapeutic Antibodies
7. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
8. Labopharm to Present Poster on Dose Titration of Once-daily Tramadol at 3rd International Forum on Pain Medicine
9. Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois
10. VeroScience Late-Breaking Abstract on Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) Accepted for Poster Presentation at American Diabetes Association 67th Scientific Sessions
11. Savient Pharmaceuticals Announces Acceptance of Two Gout-Related Abstracts for Poster Presentation at the European League Against Rheumatism (EULAR) 2007 Annual Congress
Post Your Comments:
(Date:1/15/2014)... , Jan. 15, 2014  Research and Markets ... the "Dental Consumables Market - Global Industry ... - 2018" report to their offering. ... ) Dental consumables are products which are ... impairments, for tooth restoration and in treatment of ...
(Date:1/15/2014)... , Jan. 15, 2014  Novation, the leading ... company, awarded several new IT value-added reseller (VAR) ... hospital organizations with IT goods and services at ... agreements, as well as value-added services such as ... New Novation agreements were awarded to ...
(Date:1/15/2014)... DUBLIN , January 15, 2014 ... that it has waived the Office of Fair Trading (OFT) ... the outstanding shares of ViroPharma Incorporated (NASDAQ: VPHM).   ... no longer conditional on OFT approval, and Shire expects to ... currently scheduled expiration time, subject to the satisfaction of all ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
... Ill., April 4, 2012  Archer Daniels Midland Company (NYSE: ... results of a new meta-analysis on the effects of ... The analysis, which was published March 19 by ... found clear and consistent evidence that soy isoflavone ...
... SEATTLE, April 4, 2012 /PRNewswire-iReach/ -- Global ... research services company has launched a new website ... information on the company, services offered, partner registration, ... and social networking sites. The service ...
Cached Medicine Technology:Study Confirms Soy Isoflavones Reduce Menopausal Hot Flashes 2Study Confirms Soy Isoflavones Reduce Menopausal Hot Flashes 3Global BioClinical Launches New Website 2
(Date:4/14/2014)... treat children with uncomplicated acute appendicitis is a reasonable ... fewer missed school days, according to a pilot study. ... Hospital and published online April 12 in the ... the first prospective study on nonoperative management of acute ... , Researchers enrolled 77 patients age 7 to 17 ...
(Date:4/14/2014)... 2014, Perth, Australia. Drug discovery company Proteomics International ... of a companion diagnostic (CDx) test with the ... The research team authenticated the panel of biomarkers ... samples. Seven biomarkers were validated at high stringency ... The mass spectrometry data was then cross-validated using ...
(Date:4/14/2014)... 2014) When it comes to the cost and ... Patients get the best care when they are treated ... extensive experience in their current job, according to a ... and Columbia Business School. The study was published in ... Applied Economics . , The review of more ...
(Date:4/13/2014)... STANFORD, Calif. A low-cost empowerment program for ... and sexual harassment of these girls, who live ... and are frequently attacked, a large new study ... Stanford University School of Medicine, Lucile Packard Children,s ... No Worldwide, validated the program,s effectiveness in combating ...
(Date:4/11/2014)... the processes that control brain cell production could pave ... brain-related disorders. , Scientists have gained new understanding of ... how and when nerve and brain cells are formed ... and keeps it healthy. Their findings could help explain ... which is a fundamental characteristic of many diseases including ...
Breaking Medicine News(10 mins):Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 2Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 3Health News:Longer nurse tenure on hospital units leads to higher quality care 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4
... (Nov. 8, 2011) - Patients who are not ... lesions could be treated with carotid artery stenting, according ... at The University of Texas Health Science Center at ... by lead investigator Colin M. Barker, M.D., at the ...
... , TUESDAY, Nov. 8 (HealthDay News) -- The reversal ... of receiving a new organ from a deceased donor, U.S. ... Sharing (UNOS) gave priority to potential recipients who had a ... an antigen involved in the body,s immune response to foreign ...
... on Dec. 1, University of Cincinnati research is shedding light ... AIDS and HIV infections. An Ohio survey conducted by Matthew ... AIDS remains a public health concern. Asare surveyed just ... AIDS/HIV and sex all subjects that are considered taboo ...
... Smoking bans in public places have had a spillover effect ... new study. U.S. researchers analyzed data from a nationally ... who lived in counties with total smoking bans in workplaces, ... bans at home. Homes with children were most likely ...
... TUESDAY, Nov. 8 (HealthDay News) -- New research finds older ... than younger women, suggesting that older patients may not be ... over the past three decades. Researchers analyzed U.S. government ... death rates were stable throughout the 1980s for women aged ...
... it sounds like good news: The body,s own immune ... not necessarily for the benefit of the patient. "We ... Professor Dr. Viktor Umansky, immunologist at DKFZ and University ... the immune system specifically attack tumor cells. On the ...
Cached Medicine News:Health News:Racial Disparities Still Exist for Kidney Recipients, Study Finds 2Health News:Survey finds that AIDS remains an unspeakable subject for African immigrants 2Health News:Public Smoking Bans May Spill Over to Households 2Health News:Advances in Breast Cancer Care May Not Be Reaching Older Women 2Health News:Using Viagra to combat malignant melanoma 2
... Cryo System is the first in portability and performance. ... surgeons who need a flexible, portable system with the ... CTU attaches easily to an "E" size tank and ... cryo to where it is needed.,The CTU Travel Case ...
... easy-to-use, workflow-based system designed to save you time ... the SleepWorks software and either the Connex or ... can be used for a complete range of ... EEG recording - and have superior signal quality ...
... made up of three integral components including ... Merci Balloon Guide Catheter. The system employs ... the clot has been identified using angiography, ... through a small incision in the femoral ...
... level of care you can provide to ... care program, including innovative products, standardization and ... Davol® pulsed lavage systems deliver the performance ... tissue, bacteria, and foreign material. Each provides ...
Medicine Products: