Navigation Links
Genta Announces Results of Phase 1 Study Using Genasense,Administered by Intermittent Subcutaneous Injection

Study Shows Safety and Pharmacokinetics Similar to IV Doses in Phase 3 CLL Trial

BERKELEY HEIGHTS, N.J., June 06, 2007 /PRNewswire-FirstCall/ -- Genta Incorporated announced the publication of preliminary clinical results that show the Company's lead anti-cancer drug, Genasense(R) (oblimersen sodium) injection, can be safely administered by intermittent subcutaneous (SC) injection, as well as by brief intravenous (IV) infusion. These regimens may eventually reduce or eliminate the current requirements for administering Genasense by continuous IV (CIV) infusion. The new schedules also expand the potential for use in combination with anticancer drugs that are administered on a daily or weekly basis. The data were published in proceedings of the annual meeting of the American Society of Clinical Oncology (ASCO) that was held this week in Chicago, IL.

The SC study used a new formulation of Genasense that was concentrated 5- fold greater than that used in previous Phase 3 trials. In a dose-ranging pharmacokinetic (PK) and pharmacodynamic trial, bolus SC injections of 75, 150 and 225 mg yielded dose-proportional plasma concentrations that were associated with down-regulation of Bcl-2 in blood cells. The 225 mg dose level achieved exposure PK parameters that were similar to levels achieved at the 3 mg/kg CIV daily dose level that was tested in the recent Phase 3 trial of Genasense in chronic lymphocytic leukemia (CLL).

A second phase of the program is testing escalating doses of Genasense administered as a 2-hour IV infusion. Single 150 mg doses, as well as repeated 150 mg doses administered daily for 5 consecutive days, have been well-tolerated. To date, the principal adverse events have been reversible skin reactions at the injection site on the SC schedule and transient fever on the brief IV schedule.

"These highly encouraging data represent important next steps that may greatly improve dosing
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Genta Incorporated to Present Multiple Abstracts at the Annual Meeting of the American Society of Clinical Oncology
2. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
3. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
6. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
7. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
9. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
10. Protox Announces Positive Clinical Data from Prostate Cancer Study
11. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
Post Your Comments:
(Date:1/23/2015)... Jan. 23, 2015  Now available for sale, The Armor1 ... that prevents ankle sprains by cushioning the ankle from ... securely around the outside of any shoe type and ... while still offering protection against sprains. With customers in ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ CM: ... CytoSorb® extracorporeal cytokine adsorber to reduce deadly inflammation ... receipt of $385,642, net of transaction costs, in ... Technology Business Tax Certificate Transfer Program sponsored by ...
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... BRUSSELS, Belgium, Sept. 15 ,Drais Pharmaceuticals, Inc. and ... a global agreement to develop and commercialize UNBS,5162, ... for cancer. UNBS 5162 was discovered by Unibioscreen ... United States in cancer patients with,advanced solid tumors ...
... Researchers at the Barbara,Ann Karmanos Cancer Institute ... a HER2 DNA vaccine that has shown to ... study was reported in the September 15 issue,of ... for Cancer,Research., ( http://www.newscom.com/cgi-bin/prnh/20071106/KARMANOSCANCERINSTITUTELO ,GO), Wei-Zen ...
Cached Medicine Technology:Unibioscreen and Drais Pharmaceuticals Partner to Develop and Commercialize UNBS 5162 for Treatment of Cancer 2Unibioscreen and Drais Pharmaceuticals Partner to Develop and Commercialize UNBS 5162 for Treatment of Cancer 3DNA Vaccine Developed at the Karmanos Cancer Institute Fights HER2-Positive Cancers 2
(Date:1/22/2015)... Glendale, AZ (PRWEB) January 22, 2015 Padre ... a long supporter of Pro Player Health Alliance ... with Padre Murphy's in getting everyone, including NFL greats, treated ... one of the leading groups supporting the cause in the ...
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
(Date:1/22/2015)... 2015 A new white paper by ... person-centeredness in the long-term care environment as well as ... continuum. The paper, “The Power of Person-Centeredness in Long-Term ... practices of the patient, resident and family experience in ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... Ideal for ADA-Compliant Wall Fixtures; One-Fourth the Power of ... 25 OptoElectronix today announced a unique LED-based lighting ... SSL (solid state lighting) for commercial lighting fixtures. It ... bulb at just one-fourth the power and has a ...
... ... Interactive Multimedia category for its Orthopedic Patient Education Library. , ... Margate, FL (PRWEB) June 25, 2009 -- ... best of American business. All organizations operating in the U.S.A. were eligible to submit ...
... ... fiber syrup), Yum-Yum Zymes; and Brown Rice Protein in Chocolate, Vanilla and Berry flavors at ... Center/The Venetian Resort Hotel Las Vegas, July 9-11, 2009. , ... Los Angeles, CA (PRWEB) June 25, 2009 -- Jarrow Formulas®, ...
... Foundation for VoIP Communications at Additional Invacare Locations , ... Corp., a leading global manufacturer of wheelchairs and home ... manage its new European communications network. A fully managed ... to employees at the company,s 20 sales and production ...
... 25, 2009 -- Many parents worry about their child,s exposure ... wide variety of personal care products, children,s toys, and medical ... has been associated with negative changes in endocrine function. ... Journal of Pediatrics examines the possibility that in utero ...
... be faced with harsh decisions , , FOLSOM, Pa., ... Pennsylvania families should not have to worry about losing health ... -- and urged the General Assembly to adequately fund the ... , "The nation is experiencing one of the most ...
Cached Medicine News:Health News:OptoElectronix Offers Lighting Manufacturers A Unique Integrated LED Light Engine With 1,000 Lumens Light Output 2Health News:OptoElectronix Offers Lighting Manufacturers A Unique Integrated LED Light Engine With 1,000 Lumens Light Output 3Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 2Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 3Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 4Health News:Jarrow Formulas, Inc. to Unveil Children's Natural Health Products at Upcoming Natural MarketPlace 2009 Show in Las Vegas 2Health News:Jarrow Formulas, Inc. to Unveil Children's Natural Health Products at Upcoming Natural MarketPlace 2009 Show in Las Vegas 3Health News:Verizon Private IP Quadruples Network Capacity for Invacare's European Operations 2Health News:Verizon Private IP Quadruples Network Capacity for Invacare's European Operations 3Health News:Pennsylvania Governor Rendell Urges General Assembly to Support Children's Health Insurance Program 2
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
Medicine Products: