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Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.

d CYP2C19 gene products, which are then applied to the AmpliChip microarray and hybridized. The microarray is then washed, stained, and finally scanned. Computer software then interprets the optical pattern on the scan, which indicates the particular probes bound by the patients DNA sample. The software can then determine the patients genotype and predict a phenotype.

The GeneChip System 3000Dx (Roche Diagnostics) is a dedicated microarray system that supports the AmpliChip CYP450 Test. It includes a fluidics system, microarray scanner, workstation and software to carry out all of the steps outlined above. Other compatible products microarrays are expected in the future from Roche Diagnostics and its partner, Affymetrix. Companies such as Nanogen also continue to develop a number of microarray-based tools. Together, these advances will make tailored drug therapy a reality, and patients will benefit from more consistent phamacodynamics with fewer side effects.
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