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GenVec Presents Research on New Ad35 Adenovector at ARVO

GAITHERSBURG, Md.--(BUSINESS WIRE)--May 10, 2007 - GenVec, Inc. (Nasdaq:GNVC) today announced pre-clinical research demonstrating the ability of the Company's new adenovector, Ad35, to induce and sustain protein production in the eye. Lisa L. Wei, Ph.D., GenVec's Director of Pre-Clinical Research, presented a poster, Alternate Serotype Adenovector Gives Long-Term Expression in the Eye, at the Association for Research in Vision and Ophthalmology ("ARVO") Annual Meeting in Fort Lauderdale, Florida.

Currently available treatments for ocular neovascular diseases such as wet age-related macular degeneration (AMD) involve intravitreal injections to the eye. Both patients and doctors desire less frequent injections into the eye to deliver such therapeutics. A possible strategy is the use of gene delivery systems to achieve sustained production of therapeutic proteins in the eye over a period of several months.

GenVec researchers compared the duration of expression in the eye of two different adenovectors, Ad5 and Ad35. The results showed sustained protein expression beyond 4 months in eyes treated with the Ad35 vector. With the Ad5 vector, expression diminished substantially by day 7. These results indicate that changes in the adenovector can lead to potentially important advantages in the delivery of proteins. In the case of AMD, less frequent drug administration would be of clear benefit to patients.

"It is now clear that delivery of anti-angiogenic agents to the eye can be effective in treating AMD by blocking abnormal blood vessel formation," stated Dr. Wei. "Our studies reported today demonstrated delivery of PEDF, a potent factor capable of both blocking and reversing animal models of AMD. We believe that sustained delivery of other therapeutic proteins to the eye should be possible using this technology."

About AMD

AMD affects almost thirty percent of adults between the ages of 75 an
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