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GenVec Announces New Research at AACR on Selectivity and Mechanism,of Action of TNF-Based Anti-Cancer Therapy

GAITHERSBURG, Md.--(BUSINESS WIRE)--Apr 17, 2007 - GenVec, Inc. (Nasdaq:GNVC) announced today data from two studies presented at the 97th annual meeting of the American Association of Cancer Research (AACR) that further support the use of adenovector systems to deliver the gene for tumor necrosis factor-alpha (TNF(alpha)). GenVec's lead product candidate, TNFerade(TM) biologic (TNFerade) is an adenovector, or DNA carrier, which contains the gene for TNF(alpha), a potent immune system protein with well-documented anti-cancer effects. TNFerade is currently in a pivotal Phase II/III trial for locally advanced pancreatic cancer.

GenVec researchers presented a poster entitled, "Selective delivery of tumor necrosis factor to disseminated tumors in the peritoneal cavity using targeted adenovirus vectors," (Abstract #3310) which confirmed the ability of its molecularly targeted adenovectors to selectively deliver genes to cancer cells in the peritoneal cavity in several animal models. These data demonstrated the ability of targeted vectors to penetrate tumor tissue and trigger protein expression in a dose dependent manner. This pre-clinical research suggests that tumor selective adenovectors can preferentially deliver the TNF-(alpha) gene, and holds promise as a treatment for ovarian cancer.

The mechanism of action of TNF(alpha) was the subject of a second poster presentation entitled, "The anti-tumor effects of radio-inducible TNF-alpha gene therapy target host stromal components," (Abstract #1382). In studies conducted at the University of Chicago, TNF-(alpha) delivered in an adenovector, in combination with radiation therapy, showed key effects on stromal tissues and blood vessels, both of which are critical components of human solid tumors. These results support the potential of broad activity in many tumor types.

"These results demonstrate two key findings, a potentially important mechanism of action
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