Navigation Links
GenVec Announces New Research at AACR on Selectivity and Mechanism,of Action of TNF-Based Anti-Cancer Therapy

GAITHERSBURG, Md.--(BUSINESS WIRE)--Apr 17, 2007 - GenVec, Inc. (Nasdaq:GNVC) announced today data from two studies presented at the 97th annual meeting of the American Association of Cancer Research (AACR) that further support the use of adenovector systems to deliver the gene for tumor necrosis factor-alpha (TNF(alpha)). GenVec's lead product candidate, TNFerade(TM) biologic (TNFerade) is an adenovector, or DNA carrier, which contains the gene for TNF(alpha), a potent immune system protein with well-documented anti-cancer effects. TNFerade is currently in a pivotal Phase II/III trial for locally advanced pancreatic cancer.

GenVec researchers presented a poster entitled, "Selective delivery of tumor necrosis factor to disseminated tumors in the peritoneal cavity using targeted adenovirus vectors," (Abstract #3310) which confirmed the ability of its molecularly targeted adenovectors to selectively deliver genes to cancer cells in the peritoneal cavity in several animal models. These data demonstrated the ability of targeted vectors to penetrate tumor tissue and trigger protein expression in a dose dependent manner. This pre-clinical research suggests that tumor selective adenovectors can preferentially deliver the TNF-(alpha) gene, and holds promise as a treatment for ovarian cancer.

The mechanism of action of TNF(alpha) was the subject of a second poster presentation entitled, "The anti-tumor effects of radio-inducible TNF-alpha gene therapy target host stromal components," (Abstract #1382). In studies conducted at the University of Chicago, TNF-(alpha) delivered in an adenovector, in combination with radiation therapy, showed key effects on stromal tissues and blood vessels, both of which are critical components of human solid tumors. These results support the potential of broad activity in many tumor types.

"These results demonstrate two key findings, a potentially important mechanism of action
'"/>




Page: 1 2 3

Related medicine technology :

1. GenVec Announces Update of Safety and Efficacy Data from Pivotal Phase II/III PACT Study of TNFerade at ASCO
2. GenVec Presents Research on New Ad35 Adenovector at ARVO
3. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
4. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
7. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
8. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
9. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
10. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
11. Protox Announces Positive Clinical Data from Prostate Cancer Study
Post Your Comments:
(Date:8/29/2014)... 2014  Pacific Medical Data Solutions is excited to ... . The main website, along with the site,s blog, ... services and content relevant to the medical billing industry. ... viewers can now better understand how PMDS products help ... create a more visible platform about medical billing best ...
(Date:8/29/2014)... , August 29, 2014 ... participate in the inaugural Tweetchat taking place in ... Worldwide , organised by UBM Live , ... #CPhIChat is a first of its kind global ... across the supply chain, aimed to stimulate conversations ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com ... report is available in its catalogue: ... Compliance Services Industry (U.S.): Analytics, Extensive ... to 2021, NAIC 541380 ... Testing Laboratories, Safety and Compliance ...
Breaking Medicine Technology:PMDS Announces New Website 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6
(Date:8/29/2014)... 2014 Panic attacks are extremely difficult ... of intense stress and fear, which appears with no ... causing insecurity and affecting relationships. , A panic attack ... many symptoms that patients can deal with. Anxiety, shortness ... Overcoming panic attacks is extremely important for sufferers, who ...
(Date:8/29/2014)... 29, 2014 Indosoft, Inc., a leading ... availability of monthly per-port licensing of its Q-Suite 5.7 ... center solutions, Indosoft has been successfully deploying and supporting ... large contact centers around the world for more than ... to give clients another option which complements the widespread ...
(Date:8/29/2014)... 2014 Champion boxers Laila Ali and ... appearing on the annual MDA Show of Strength Telethon ... on ABC television stations across the country. , ... of “All In, with Laila Ali," will introduce a ... the Muscular Dystrophy Association's nationally broadcast show. , Ortiz ...
(Date:8/29/2014)... UWDress.com, one of the most famous dress ... of 2014 floor length bridesmaid dresses . Additionally, ... items. According to the company’s marketing specialist, all its ... rate (up to 60 percent off) before September 10. ... special neckline: strapless, one-shoulder, bateau and more. The main ...
(Date:8/29/2014)... As reported by CNN.com in the article ... of admitting that you need help for a prescription drug ... highlights the fact that if you simply try to find ... by all of the information that is available online. Although ... it is still possible to get help. The statistics from ...
Breaking Medicine News(10 mins):Health News:60 Second Panic Solution Review Exposes Simple Panic Attacks Remedy 2Health News:Indosoft Offers Monthly Usage Licensing Terms 2Health News:Champion Boxers Fight Back Against Muscle Disease 2Health News:Champion Boxers Fight Back Against Muscle Disease 3Health News:2014 Floor Length Bridesmaid Dresses for Sale at UWDress.com 2Health News:What to Know When Seeking Drug Addiction Help 2Health News:What to Know When Seeking Drug Addiction Help 3
... small Pacific Islands, which consists of the some of ... the global conservation map//, and is said to be ... ,Martin Puta Tofinga, Minister of Environment, ... announced the establishment of the Phoenix Islands Protected Area ...
... under the Freedom of Information Act have revealed that hospitals ... use of car parks. The BBC reports that trusts had ... this service. ,The hospitals, which earned the maximum ... The Department of Health figures show that University Hospital Birmingham ...
... in the April issue of Radiology says that ultrasound is ... and also assess// the effectiveness of chemotherapy. Researchers at the ... a study where they examined the largest group of women ... cancer during pregnancy. ,"Ultrasound identified 100 percent of ...
... that promotes body growth, is produced in the brain according ... // The researchers have been able to trace the origin ... the brain in charge of memory and emotion – called ... the fact that more growth hormones are produced in females ...
... on cancer have proposed that cancer patients should be ... their care. // ,National standards in the ... standards could be enforced by the National Institute of ... the aspects of cancer services that would be standardized ...
... alcohol is not a sign that drinkers remain uninfluenced by ... like red bull after alcohol, to maintain sobriety. // ... after drinking vodka mixed with red bull felt less drunk, ... Souza-Formigoni, PhD, in a news release said “The person is ...
Cached Medicine News:Health News:Phoenix Islands To Be Protected Under Global Conservation Map 2Health News:Phoenix Islands To Be Protected Under Global Conservation Map 3Health News:Charging Car Park Fees From Cancer Patients Is Morally Wrong, Says Macmillan Cancer Relief 2Health News:Ultrasound Can Detect Breast Cancer in Pregnant Women 2Health News:Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety? 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: