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Gemin X Presents Positive Preclinical Data of GX15-070 in Infant,ALL at AACR Meeting

inhibitor GX15-070."

Gemin X is currently conducting several clinical trials of GX15-070 in multiple cancer types as a combination therapy and as a single agent. Gemin X recently initiated a Phase 1b trial with GX15-070 in combination with bortezomib in patients with mantle cell lymphoma (MCL) and a Phase 1/2 clinical trial in combination with docetaxel in patients with non-small cell lung cancer. GX15-070 is also in Phase 2 clinical trials in patients with Hodgkin's Lymphoma, myelofibrosis with myeloid metaplasia, myelodysplastic syndrome, and follicular lymphoma both as single agent and in combination with rituximab. In multiple Phase 1 studies, GX15-070 was well-tolerated and resulted in clinical and biological activity.

About Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a fast-growing cancer of the white blood cells, which the body uses to fight infections. The disease is characterized by the bone marrow's overproduction of immature, unformed cells called blasts that would normally develop into mature lymphocytes. These abnormal blasts cannot fight infections, grow quickly, and interfere with normal red blood cells, white blood cells, and platelets. Approximately 4,000 new cases of ALL are diagnosed in the United States each year, and it is fatal if left untreated, because the disease can spread to the bloodstream and organs quickly. It mainly appears in children younger than 10, but one-third of cases are in adults. ALL is the most common form of infant leukemia.

Gemin X Biotechnologies Inc. specializes in the discovery and development of novel small molecule cancer therapeutics based on the regulation of apoptosis, the body's natural ability to destroy injured or damaged cells. Gemin X's lead product, GX15-070, is a small molecule, pan-inhibitor of Bcl-2 proteins and is currently in Phase 2 clinical trials. Gemin X is also developing a small molecule that induces apopt
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