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Gemin X Biotechnologies Announces Publication in Blood of Positive,Preclinical Data of Lead Compound in Mantle Cell Lymphoma

MONTREAL--(BUSINESS WIRE)--May 15, 2007 - Gemin X Biotechnologies Inc. announced today that a report published in the journal Blood demonstrated that its lead compound, obatoclax (GX15-070), induced cell death in vitro in Mantle Cell Lymphoma (MCL) cell lines and primary cells from 11 MCL patients. Obatoclax (GX15-070) is a small molecule specifically designed to inhibit all relevant members of the Bcl-2 protein family, a validated cancer target, thus restoring the natural cell death process of apoptosis.

The study, which appears in the May 15 print edition of Blood, is titled, "The BH3-mimetic GX15-070 synergizes with Bortezomib in Mantle Cell Lymphoma by enhancing Noxa-mediated activation of Bak." It was led by Patricia Perez-Galan et al., from the Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

According to the report, GX15-070 was active in cells bearing defective DNA damage sensor genes or cell cycle regulators. Additionally, the compound synergized with bortezomib (Velcade(R)), a proteasome inhibitor, such that MCL cells became sensitized to low doses of bortezomib. Bortezomib was shown to induce the pro-survival Bcl member, Mcl-1, which causes resistance to the drug. Inhibition of Mcl-1 by GX15-070, in contrast, overcame this resistance. This positive preclinical activity of GX15-070 led to an increased activation of the apoptotic pathway, while showing no significant cytotoxic effect in normal cells from healthy donors when used both alone and in combination with bortezomib.

"The results of this study show that a small molecule inhibitor, such as obatoclax (GX15-070) that modulates the Bcl-2 pathway, is a rational approach for the treatment of MCL," said Gordon Shore, Chief Scientific Officer of Gemin X. "Its ability to enhance the effects of bortezomib by overcomi
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