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Gemin X Announces Publication of Preclinical Data of GX15-070 in,Multiple Myeloma in Blood

X15-070 is also in Phase 2 clinical trials in patients with Hodgkin's Lymphoma and in myelofibrosis with myeloid metaplasia. In multiple Phase 1 studies, GX15-070 was well-tolerated and resulted in clinical and biological activity.

The study, which is currently available in the online edition Blood, is titled, "Pre-clinical studies of the pan-Bcl inhibitor obatoclax (GX15-070) in multiple myeloma," was led by Dr. Suzanne Trudel, et al., of the Mayo Clinic of Medicine, Scottsdale, AZ, and Princess Margaret Hospital, Toronto, ON. The report will also appear in the print edition of Blood.

About Multiple Myeloma (MM)

Multiple myeloma is a type of cancer caused by malignant plasma cells that are spread throughout the bone marrow, resulting in bone erosion and interference with bone marrow and immune system function. MM is incurable and is characterized by frequent early responses to treatment followed by relapse. The American Cancer Society estimates that nearly 11,000 Americans will die of MM in 2007, and the 5-year survival rate for the disease is approximately 33 percent.

Gemin X Biotechnologies Inc. specializes in the discovery and development of novel small molecule cancer therapeutics based on the regulation of apoptosis, the body's natural ability to destroy injured or damaged cells. Gemin X's lead product, GX15-070, is a small molecule, pan-inhibitor of Bcl-2 proteins and is currently in Phase 2 clinical trials. Gemin X is also developing a small molecule that induces apoptosis in p53-defective cancers. Gemin X is privately held and is located in Montreal, Quebec and Malvern, Pennsylvania. For additional information please visit Gemin X at www.geminx.com

Contact

MacDougall Biomedical Communications
Jennifer Greenleaf, 508-647-0209
or
Gemin X Biotechnologies
Sherri Carenzo, 610-640-5735 Ext. 16
scarenzo@geminx.com


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