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GSK'S Pazopanib Shows Positive Results in Patients with Advanced,Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma

in metastatic renal cell carcinoma (RCC): interim results of a phase II randomized discontinuation trial (RDT). Presented at the 2007 ASCO Annual Meeting, Chicago, USA Abstract number 5031. (4) Murai, M. and Oya, M. Renal cell carcinoma: etiology, incidence and epidemiology. Curr. Opin. Urol. 2004;14, 229-233. (5) Parkin, M., Bray F. et al. Global Cancer Statistics. CA Cancer J Clin. 2005;55:74-108 (6) VEG102616 study protocol (7) Motzer, R.J. and P. Russo, Systemic therapy for renal cell carcinoma. J. Urol. 2000; 163:408-417. (8) Garcia, JA., Rini B. Recent progress in the management of advanced renal cell carcinoma. CA Cancer J Clin. 2007 Mar- Apr;57(2):112-25. (9) Friedlander, M., et al. Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: initial results of a Phase II study. Presented at the 2007 ASCO Annual Meeting, Chicago, USA Abstract number 5561 (10) VEG104450 study protocol (11) Sleiffer, S. et al. A Phase II study of pazopanib (GW786034) in patients with relapsed or refractory soft tissue sarcoma (STS): an EORTC soft tissue and bone sarcoma group study (EORTC62043). Presented at the 2007 ASCO Annual Meeting, Chicago, USA Abstract number 10031 (12) EORTC protocol 62043

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