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GSK'S Pazopanib Shows Positive Results in Patients with Advanced,Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma

ase II study is evaluating the effect of pazopanib in patients with advanced STS who have failed prior therapy for advanced disease. Currently there is no standard treatment for such patients. (12) Of 80 patients included in the first stage of this study, 27 (34%) achieved progression-free survival at 12 weeks.

Pazopanib was evaluated in four types of STS in the first stage of the study: leiomyosarcoma, liposarcoma, synovial sarcoma and other soft tissue sarcomas. Pazopanib demonstrated activity in all tumor types except liposarcoma, and the study is ongoing to further investigate activity in the responsive tumor types. The most common AEs recorded were hypertension, fatigue, hair color change, and nausea. Please see safety considerations below.

About pazopanib

Pazopanib is an investigational, oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and c-kit. Pazopanib is currently in Phase III development for the treatment of advanced or metastatic RCC, after completing patient enrollment several months ahead of schedule, and is also being studied in a number of other trials across various tumor types.

Safety Considerations

In more than 1000 patients treated to date with pazopanib in clinical trials, serious but uncommon (<1%) reports of bowel perforation, myocardial infarction/angina and cerebrovascular accidents/transient ischemic attacks have been reported. The most common laboratory abnormality was an elevation in liver transaminase which occurred as an asymptomatic, reversible event.

About GlaxoSmithKline

GlaxoSmithKline -- one of the world's leading research-based pharmaceutical and healthcare companies -- is committed to improving the quality of human life by enabling people to do more, feel better, and live longer. For company information, visit GlaxoSmithKline at http://www.gsk.c
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