Navigation Links
GSK and Adolor Announce Preliminary Results from Phase 3 Safety,Study of Alvimopan (Entereg/Entrareg)

LONDON & EXTON, Pa.--(BUSINESS WIRE)--Apr 9, 2007 - GlaxoSmithKline (LSE and NYSE:GSK) and Adolor Corporation (Nasdaq:ADLR) today announced data from Study 767905/014 and provided an update on the clinical development program for alvimopan (Entereg/Entrareg(R)).

Study 014, a Phase 3, double blind, placebo-controlled (12 month) study, was designed to evaluate the long-term safety and tolerability of alvimopan 0.5 mg twice daily in patients taking opioids for chronic non-cancer pain and experiencing opioid-induced bowel dysfunction (OBD). A total of 805 patients were enrolled into the study and randomized 2:1; a total of 538 patients received alvimopan and 267 received placebo.

Consistent with findings from previous studies the most common adverse events observed in Study 014 were those affecting the gastrointestinal (GI) tract, including abdominal pain and diarrhea. The incidence of GI adverse events observed was similar between patients treated with alvimopan (40%) and placebo (35%).

While the proportion of patients experiencing serious adverse events was similar between those treated with alvimopan (13%) and placebo (11%), a numerical imbalance was observed in the number of cardiovascular (CV) and neoplasm cases categorized as serious adverse events among alvimopan-treated patients.

Preliminary findings from Study 014 are outlined below, together with information regarding actions taken by GSK and Adolor regarding the two ongoing alvimopan studies.

Cardiovascular Adverse Events

Results from a six-month interim analysis of Study 014, previously announced in November 2006, showed an increase which was not statistically significant in the reported incidence of serious CV adverse events in patients receiving alvimopan relative to placebo. Results from completed Study 014 showed an increase in myocardial infarctions and all CV SAEs reported by patients treated with alvimopan c
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
3. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
6. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
7. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
9. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
10. Protox Announces Positive Clinical Data from Prostate Cancer Study
11. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
Post Your Comments:
(Date:7/6/2015)... July 6, 2015 E-QURE Corp (OTCQB: EQUR), ... live at VirtualInvestorConferences.com on July 9, 2015. ... http://tinyurl.com/e-qure-presentation This will be a ... ask the company questions in real-time - both in ... trade booth." If attendees are not able to join ...
(Date:7/6/2015)... -- Celtaxsys, Inc., a clinical stage pharmaceutical development company ... orphan inflammatory disease indications, announced today that it has ... (FDA) to begin a Phase 2 clinical trial of ... patients in the US. The regulatory submissions to the ... be filed soon after. This groundbreaking clinical study, testing ...
(Date:7/6/2015)... , July 6, 2015  OncoSec Medical Inc. ... intratumoral cancer immunotherapies, today announced the appointment of ... of Vice President of Market Development, effective July 6, ... for evaluating, designing, and executing on the company,s market ... "I,m very excited to welcome Joann to the ...
Breaking Medicine Technology:E-QURE Corp to Webcast, Live, at VirtualInvestorConferences.com July 9 2Celtaxsys, Inc. Gains FDA Clearance for Landmark Phase 2 Trial of Anti-Inflammatory Treatment for Cystic Fibrosis (CF) 2Celtaxsys, Inc. Gains FDA Clearance for Landmark Phase 2 Trial of Anti-Inflammatory Treatment for Cystic Fibrosis (CF) 3OncoSec Medical Appoints Joann V. Lofgren as Vice President of Market Development 2OncoSec Medical Appoints Joann V. Lofgren as Vice President of Market Development 3
(Date:7/6/2015)... Cucamonga, Ca (PRWEB) , ... July 06, 2015 , ... ... distinguished awards in 2015, marking him as an attorney who has sharp ... Vargas received both a Client Distinction Award for 2015 from Martindale-Hubbell and a Top ...
(Date:7/6/2015)... ... July 06, 2015 , ... In order to ... American Orthopaedic Society for Sports Medicine ( AOSSM ) will present ten research ... As a leader in orthopaedic sports medicine, AOSSM annually provides more than ...
(Date:7/6/2015)... ... July 06, 2015 , ... Invitation to ... yet there is a large gap between the unmet health priorities in the ... health outcomes and reduce unnecessary or ineffective treatments or procedures. , This milestone ...
(Date:7/6/2015)... ... July 06, 2015 , ... Understanding the new ... ADVOCATE is leading the transition. ADVOCATE, the only 100% radiology, revenue cycle management ... Tips for ICD-10. The ten tips are timely and relevant guidelines to help ...
(Date:7/6/2015)... SAN DIEGO, CA (PRWEB) , ... July 06, 2015 , ... ... , will deliver the keynote address at the 4th Annual Seedstock Sustainable Agriculture Conference ... , This year’s conference , held at the University of California-San Diego, will ...
Breaking Medicine News(10 mins):Health News:Fernando D. Vargas Awarded Top Honors in Personal Injury Law for 2015 from Two Respected Independent Organizations 2Health News:Fernando D. Vargas Awarded Top Honors in Personal Injury Law for 2015 from Two Respected Independent Organizations 3Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 2Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 3Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 4Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 5Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 6Health News:Columbia Nursing Nairobi Summit: Setting a Clinical Research Agenda for Africa 2Health News:ADVOCATE Takes the Lead to Ensure ICD-10 Success: “Top 10 Tips for ICD-10” 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 3Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 4
... First ,Webisode, Featuring Guest, Hosts, Live Call-ins, Interactive Blogs on ... ... Dealing With Change, BOCA RATON, Fla., June 18 ... webisode -- a,transformational show called "The Insight" featuring three hosts ...
... Raise $2 Million Dollars in ... Series ... Investment,Banking and Business Development Services Firm to Emerging and Middle,Market Enterprises, ... in Series A capital for Pop! Technology, a creator of,active, barcode ...
... BlueCross,BlueShield of South Carolina Foundation will grant $1.5 ... Carolina,Nurses Foundation, Inc. Distributed over three years, the ... nurses who will then become faculty in,nursing education ... experiencing a serious nursing shortage due to the,retirement ...
... Calif., June 18 Accuray,Incorporated (Nasdaq: ARAY ), ... that its president and chief executive officer, Euan S.,Thomson, ... on Thursday, June 26, 2008 at 10:15 a.m. EDT ... presentation will be available online from the,investor relations page ...
... out the best place to live by eavesdropping on ... birds a communication and behavioral trait so strong ... in places they otherwise would have avoided. , This ... had previously been understood, researchers say, and that these ...
... Certification Demonstrates Commitment to Securing Confidential Customer ... Data for Health Care Technology Leader, ... TriZetto Group Inc., a leader in health care technology solutions,serving ... Wednesday (June 18) that it has maintained the Verizon Business,Security ...
Cached Medicine News:Health News:A South Florida Premiere 2Health News:Pop! Technology Goes Growthink 2Health News:BlueCross' $1.5 Million Nursing Scholarships to Ease Nursing Faculty Shortage 2Health News:BlueCross' $1.5 Million Nursing Scholarships to Ease Nursing Faculty Shortage 3Health News:Accuray Incorporated's CEO to Speak at Jefferies Second Annual Healthcare Conference 2Health News:Birds communicate reproductive success in song 2Health News:Birds communicate reproductive success in song 3Health News:TriZetto Maintains Prestigious Verizon Business Security Certification for Sixth Consecutive Year 2Health News:TriZetto Maintains Prestigious Verizon Business Security Certification for Sixth Consecutive Year 3Health News:TriZetto Maintains Prestigious Verizon Business Security Certification for Sixth Consecutive Year 4
... Portable Slit-Lamp. Rechargeable, cordless ... for any purpose , Easy selection ... blue filter , Extra-bright halogen lamp ... main and extra ,power pack , ...
The PillCam™ ESO video capsule is specifically designed to view the inner lining of the Esophagus. The capsule is equipped with miniature cameras on both ends and is about the size of a multi-v...
World's first commercially available vacuum assisted biopsy device for MRI....
... Now you can perform stereotactic, ultrasound ... the convenience of your office. Use the ... safer, easier and more clinically advanced method ... its best for the women who trust ...
Medicine Products: