Navigation Links
Further Statistical Analysis of the Recent Phase III trial on Lead,Product M6G Shows Additional Benefits

* Statistically significant reduction in sedation during the early post-operative period compared to morphine

* Statistically significant reduction in nausea in the female patient population compared to morphine

Cambridge, UK, 8th June 2007 - CeNeS Pharmaceuticals plc (AIM: CEN), the Cambridge based biopharmaceutical company, announces additional data from post-hoc analysis of the recent Phase III trial (M6G022) of M6G (morphine-6-glucuronide) in over 500 patients with post-operative pain. The Phase III data released on 20 February 2007 confirmed M6G's planned product profile and showed that M6G provided equivalent pain relief to morphine but induced significantly less post-operative nausea and vomiting (PONV).

Sedation

Analysis of the sedation data from the M6G022 trial showed statistically significant reductions in sedation in the M6G group compared to morphine in the first four hours after surgery reaching a reduction of 15% at 4 hours (p=0.007). Discussions with clinicians support the view that this is a clinically important benefit. Opiates such as morphine are well known to induce sedation and respiratory depression. Excessive sedation in the early post-operative period is associated with depression of the respiratory system, which can, in some cases, be fatal.

Nausea in female patients

It is well established that female patients undergoing surgery have a higher risk of experiencing nausea and vomiting in the post-operative period. New data analysing the female patient group (approximately 70% of the patients in the M6G022 Phase III clinical trial) showed a statistically significant reduction in nausea in the period 6-24 hours after treatment (p=0.034). The overall incidence and severity of post-operative nausea in the M6G arm for both males and females was 27% less than that observed in the morphine arm but narrowly missed statistical significance, p=0.052 (versu
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Molecular Target of Bradmers Neuradiab Further Validated by Independent Findings
3. Phase III Clinical Trial with 4-Month Long-Acting Formulation of Triptorelin: Ipsen Decides Not to Perform Further Administration
4. New Data on Market-Leading Velcade (Bortezomib) for Injection Further Strengthen Role in Previously Treated Multiple Myeloma
5. Liponex Inc. Reports Further Analysis of CRD5 Phase I/II Clinical Trial Data
6. MIV Therapeutics Announces Pivotal Test Results Further Validating Company Stent Coatings Meet Critical FDA Fatigue Guidelines
7. Neurologix Announces Publication of Landmark Gene Therapy Study Demonstrating Safety and Statistically Significant Improvement in Patients With Advanced Parkinsons Disease
8. Medivations Dimebon Maintains Statistically Significant Benefit on All Five Efficacy Endpoints in Alzheimers Disease Trial After One Year of Therapy
9. Repros Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism
10. Positive Statistical Analysis from Synthetic Bloods Oxycyte Traumatic Brain Injury Trial Indicates Achievement of Primary Endpoint
11. ISTA Pharmaceuticals Announces Statistically Significant Preliminary Results From its U.S. Phase II/III Clinical Study Of Bepotastine
Post Your Comments:
(Date:9/2/2014)... Sept. 2, 2014 Bluegrass Vascular ... focused on innovating lifesaving devices and methods for ... Dr. Gabriele Niederauer , a seasoned senior ... the recent closure of Series A financing, BVT ... Surfacer™ Inside-Out Access Catheter System, a proprietary system ...
(Date:9/2/2014)... 2014  Soligenix, Inc. (OTCQB: SNGX) (Soligenix ... company focused on developing products to treat ... unmet medical need, as well as developing ... promising preliminary results from a preclinical study ... a non-human primate (NHP) lethal aerosol exposure ...
(Date:9/2/2014)... Sept. 2, 2014  Sinovac Biotech Ltd. (NASDAQ: ... China , today announced that the Company,s management ... , Morgan Stanley Global Healthcare Conference, to be held ... 10, 2014. , Morgan Stanley Asia Pacific Healthcare Day, ... 11, 2014. , Aegis Healthcare & Technology Conference, to ...
Breaking Medicine Technology:Bluegrass Vascular Technologies Names Dr. Gabriele Niederauer President And CEO 2Soligenix Announces Positive Survival Results with Heat Stable Ricin Toxin Vaccine 2Soligenix Announces Positive Survival Results with Heat Stable Ricin Toxin Vaccine 3Soligenix Announces Positive Survival Results with Heat Stable Ricin Toxin Vaccine 4Soligenix Announces Positive Survival Results with Heat Stable Ricin Toxin Vaccine 5Soligenix Announces Positive Survival Results with Heat Stable Ricin Toxin Vaccine 6Soligenix Announces Positive Survival Results with Heat Stable Ricin Toxin Vaccine 7Soligenix Announces Positive Survival Results with Heat Stable Ricin Toxin Vaccine 8Sinovac to Participate in Upcoming Investor Conferences 2
... Nov. 21, 2011   Switzerland-based Ferring Pharmaceuticals today ... Interpace Parkway in Parsippany, N.J.  The new facility will ... expansion is expected to generate jobs in the New ... The U.S. Operations Center will be a ...
... a leader in developing minimally invasive medical devices used ... the gastrointestinal tract, announces today that they have signed ... is a leading global provider of healthcare products and ... Covidien will acquire all of the outstanding capital ...
Cached Medicine Technology:Ferring Pharmaceuticals To Develop Major Corporate Center in Parsippany, New Jersey 2BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 2BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 3
(Date:9/2/2014)... (HealthDay News) -- The quality of Americans, diets has ... between the rich and poor is growing, a new ... evidence to date that the extensive efforts by many ... having some payoff, but it also indicates that these ... a doctoral student in the department of nutrition at ...
(Date:9/2/2014)... 2014 (HealthDay News) -- When it comes to excess pounds ... a new study finds. The research found that belly ... odds for high blood pressure more than overall body fat. ... high blood pressure. But it wasn,t clear how the location ... researchers at University of Texas Southwestern Medical Center in Dallas. ...
(Date:9/2/2014)... 02, 2014 North America Resectoscopes ... Market Outlook to 2020? provides key market data ... provides value, in millions of US dollars, volume ... within market segments –,     Rigid ... Reusable) Electrodes and Bipolar (Disposable and Reusable) Electrodes). ...
(Date:9/2/2014)... 02, 2014 USARAD Holdings Inc. ... telemedicine solutions provider, including SecondOpinions.com® – consumer division ... technologically advanced services. The telemedicine industry pioneer is ... Kuwait. , Founded and established in 1963 as ... Shifa began as a maternity care hospital with ...
(Date:9/2/2014)... 02, 2014 A little bit of ... sometimes the onset of irritability, sadness, or apathy can ... September 2014 Harvard Health Letter. , "Mood-related ... stresses. If they occur for long periods, cause significant ... to seek help," says Dr. Nancy Donovan, an instructor ...
Breaking Medicine News(10 mins):Health News:Quality of U.S. Diet Improves, Slightly 2Health News:'Spare Tire' May Be Especially Bad for Your Blood Pressure 2Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 2Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 3Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 4Health News:USARAD Holdings Inc. SECONDOPINIONS.COM® Partners With Prestigious Dar Al Shifa Hospital In Kuwait 2Health News:USARAD Holdings Inc. SECONDOPINIONS.COM® Partners With Prestigious Dar Al Shifa Hospital In Kuwait 3Health News:USARAD Holdings Inc. SECONDOPINIONS.COM® Partners With Prestigious Dar Al Shifa Hospital In Kuwait 4Health News:When a Mood Swing Signals Trouble, From the September 2014 Harvard Health Letter 2
... 5 SectorWatch.biz announces the,availability of MarketStats for ... message boards relative to the healthy food market.,MarketStats ... the,opportunity for investors to respond with articles and ... by visiting: http://www.SectorWatch.biz ,-a division of FiSpace.net, ...
... a major website re-design, aimed specifically toward potential clients, with ... ... New York, NY (PRWEB) August 5, 2008 ... website re-design, aimed specifically toward potential clients, with improved navigability, ...
... and genetic profiling is proving many skeptics wrong. A recent ... privacy concerns. From dating, through genealogy, to preventative heart medication, ... decisions is gaining acceptance. , ... Carlsbad, Calif. (PRWEB) ...
... Properties, Inc. (NYSE: NHP ) announced today the ... to its Board of Directors. "Jeff,and Rick are remarkably ... D. Miller, NHP,s Chairman of the Board. "We look,forward ... maintain,its reputation for delivering excellent shareholder value.", Dr. ...
... to Recruit and Retain Top Notch Hospital Employees, ... Virginia Hospital Center, Arlington County,s newest child care,program, has ... by Bright Horizons Family Solutions, this center is for ... live or work in,Arlington County., Child Care & ...
... participate in fewer sports but watch less TV , , ... United States are less active and less likely to participate ... , They analyzed data from the 2003 National Survey of ... U.S. children were inactive, while 73.5 percent were physically active ...
Cached Medicine News:Health News:SectorWatch.biz Issues MarketStats for Healthy and Organic Companies ORGC, DF, WFMI, LWAY, COIN, and TOF 2Health News:Re-Designed Legal Website Includes Blog 2Health News:DNA Testing and Genetic Profiles Help Avoid Broken Hearts Polls Reveal 2Health News:DNA Testing and Genetic Profiles Help Avoid Broken Hearts Polls Reveal 3Health News:Dr. Jeffrey Rush and Richard Gilchrist Join NHP Board of Directors 2Health News:Dr. Jeffrey Rush and Richard Gilchrist Join NHP Board of Directors 3Health News:Dr. Jeffrey Rush and Richard Gilchrist Join NHP Board of Directors 4Health News:Virginia Hospital Center Opens Child Care Center for Employees and Community 2Health News:Virginia Hospital Center Opens Child Care Center for Employees and Community 3Health News:Immigrant Children Less Likely to Exercise 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: