Navigation Links
From Clinical Cancer Research: Rethinking Therapeutic Cancer,Vaccine Trials

PHILADELPHIA, July 3, 2007-- Ongoing therapeutic cancer vaccine trials have yet to show evidence of vaccines spurring a patient’s immune system to shrink tumors -- yet patients who receive these vaccines in trials tend to live longer and respond better to subsequent treatment. In the July 1 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, a team of National Cancer Institute researchers asks a fundamental question: are we looking at cancer vaccine trials the wrong way?

“Cancer Vaccines: Moving Beyond Current Paradigms,” Jeffrey Schlom, et. al., Clinical Cancer Research, July 1, 2007, Volume 13, No. 13, pages 3776-3782.

In a review of five prostate cancer vaccine trials, NCI researchers offer evidence that patients who receive vaccines may respond better to subsequent chemotherapy or hormone treatment. The specific results – or endpoints – of these clinical trials, however, were not the long term survival of patients, but rather the degree to which the vaccine caused tumors to shrink. According to the researchers, since they didn’t achieve their primary endpoints, these vaccines may be abandoned as dead-ends, despite their real therapeutic value in terms of prolonging patient survival.
“Clinical data are providing evidence that patients are living longer following vaccination, despite the fact that trials do not show the vaccines can induce the immune system into shrinking tumors,” said Jeffrey Schlom, Ph.D., chief of the Laboratory of Tumor Immunology and Biology at the National Cancer Institute. “The data suggests that the scientific community and regulatory committees ought to rethink the design of clinical vaccine trials and our current approach to measuring the effectiveness of a cancer vaccine.”

According to the researchers, it may be more helpful to think of the effectiveness of a v
'"/>




Page: 1 2 3

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
11. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
Post Your Comments:
(Date:9/30/2014)... 30, 2014   Easy Breathe , the fastest ... announced that it now offers the revolutionary AirSense ... the first sleep apnea therapy devices with internal cellular ... to track and share real-time data on each user,s ... CPAP therapy.  In addition, the internal modem allows the ...
(Date:9/30/2014)... ORANGE , N.J. and NEW BRUNSWICK, N.J., Sept. 30, ... affiliation agreement that allows Kessler Foundation and New ... advance biomedical research, education and patient care programs ... president and chief executive officer of Kessler Foundation ... New Jersey Health Foundation. "The experience ...
(Date:9/30/2014)... , Sept. 30, 2014 The Eastern European ... established medical-device providers as well as new medical-device manufacturers ... while simultaneously looking at ways to reduce the cost ... distributors is one of the effective means to achieve ... distribution market in Eastern European and provides profiles of ...
Breaking Medicine Technology:Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 2Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 4Kessler Foundation Partners with New Jersey Health Foundation To Start Innovative Companies To Change the Lives of People with Disabilities 2Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3
(Date:9/30/2014)... New York, NY (PRWEB) September 30, 2014 ... and falling demand have hampered growth in the ... Popular diets have caused consumers to moderate their ... growing consumer preferences for premium varieties shrunk the ... bread products. Successful operators proactively responded by introducing ...
(Date:9/30/2014)... been awarded a three-year $1.7 million grant from ... new imaging technologies and data analysis techniques that ... of neurons in the brain interact to process ... the precise interactions between millions of nerve cells ... alterations in these interactions that may be responsible ...
(Date:9/30/2014)... September 30, 2014 The American ... to help diabetics curb their sweet tooth, but the ... this September, suggests that zero-calorie sweeteners may actually ... diabetes. , The Weizmann Institute of Science in ... artificial sweeteners to mice, the mice developed glucose intolerance. ...
(Date:9/30/2014)... 2014 Regenerative Medicine Solutions (RMS) is ... in Nashville, Tennessee. RMS welcomes the launch of an ... expansion of a new treatment center for the Lung ... Apnea Institute to Nashville, the hope is to bring ... both diagnosed and undiagnosed. With Nashville being a hub ...
(Date:9/30/2014)... 30, 2014 (HealthDay News) -- Medicare should cover low-dose ... risk for the disease, a coalition of more than ... which includes the Lung Cancer Alliance, the Society of ... Cancer Society and the American Society of Clinical Oncology, ... the U.S. Centers for Medicare & Medicaid Services (CMS). ...
Breaking Medicine News(10 mins):Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:UMD receives inaugural BRAIN Initiative Award 2Health News:Artificial Sweeteners May be Linked to Greater Diabetes Risk 2Health News:Regenerative Medicine Solutions Expanding 2Health News:Groups Call for Medicare Coverage of Lung Cancer Screening 2
... Small Business Committee Leaders to Press for Affordable ... 24 In advance of tomorrow,s,Finance Committee hearing ... Kerry (D-Mass.) and Olympia J. Snowe (R-Maine), Chairman ... and Entrepreneurship,sent a letter to the leaders of ...
... from a Phase I/II clinical trial of a novel ... In 26 patients with advanced solid tumors, treatment with ... yielding plasma concentrations above the expected therapeutic threshold, says ... in Montreal, Canada. Thallion has produced and tested ...
... seven exceptionally talented and creative investigators in the early ... Health Science (NIEHS), part of the National Institutes of ... made under NIEHSs Outstanding New Environmental Sciences (ONES) program. ... of our efforts to help establish the careers of ...
... supports vitamins for respiratory health , , WEDNESDAY, Oct. 24 (HealthDay ... of drinks a day may help keep the doctor away, ... daily dose of alcohol helps the heart, this study suggests ... for smokers. , "This is the biggest study that,s ever ...
... Oct. 24 Thelen Reid Brown Raysman &,Steiner ... group has,successfully assisted long-time client The Doctors Company ... major provider of healthcare liability,insurance, for an aggregate ... share in cash. (Logo: http://www.newscom.com/cgi-bin/prnh/20071016/AQTU238LOGO ) ...
... trend, PHILADELPHIA, Oct. 24 Governor Edward ... Reduction of Error,Fund (Mcare) claims have dropped by ... result of reforms, more insurers are writing malpractice ... when it comes to medical malpractice,",Governor Rendell said ...
Cached Medicine News:Health News:Kerry, Snowe Push Finance Committee on Small Business Health Care 2Health News:Kerry, Snowe Push Finance Committee on Small Business Health Care 3Health News:Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent 2Health News:NIEHS awards outstanding new environmental scientists 2Health News:Drink or Two a Day May Help Lungs 2Health News:Drink or Two a Day May Help Lungs 3Health News:Drink or Two a Day May Help Lungs 4Health News:Thelen Assists The Doctors Company in Acquisition of SCPIE Holdings Inc. 2Health News:Governor Rendell Says Mcare Claims and Costs Are 50 Percent Lower Than in 2003 2
The CK method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase activity in serum and plasma...
For the quantitative in vitro determination of Cholesterol in serum and plasma....
For the quantitative in vitro determination of Alanine Aminotransferase (ALT) in serum and plasma....
... introduces the Tag-It™ Cystic Fibrosis Kit, the ... genotyping. With validated performance criteria, this highly ... superior mutation coverage for carrier screening in ... in newborns. ,The Tag-It™ Cystic Fibrosis ...
Medicine Products: