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First single breast cancer study to show significant survival,benefit for women switching from tamoxifen to Arimidex

en with advanced breast cancer. Advanced breast cancer in postmenopausal women in whom tamoxifen or other anti-oestrogen therapy has failed. Pre-operative therapy in postmenopausal women with localised hormone receptor positive breast cancer, to allow subsequent breast-conserving surgery in women not originally considered candidates for breast-conserving surgery. Subsequent treatment after surgery should be in accordance with standard of care.

· Exemestane (AromasinÒ), Pfizer: Indicated for the adjuvant treatment of postmenopausal women with oestrogen receptor positive invasive early breast cancer, following 2-3 years of initial adjuvant tamoxifen therapy. AromasinÒ is indicated for the treatment of advanced breast cancer in women with natural or induced postmenopausal status whose disease has progressed following anti-oestrogen therapy. Efficacy has not been demonstrated in patients with oestrogen receptor negative status. Previously, the IES study has demonstrated an overall survival benefit for exemestane in only hormone receptor positive /unknown patients. [vi]

For further information, or to arrange an interview with a breast cancer specialist or patient, please contact

Joanne Wunder, Ogilvy PR

Tel: 020 7309 1065

Email: joanne.wunder@uk.ogilvypr.com> joanne.wunder@uk.ogilvypr.com

OR

Stephen Cull, AstraZeneca UK Ltd

Tel: 01582 836344

Mobile: 07825 530052

Email: stephen.cull@astrazeneca.com

_____

[i] Kaufmann M, Jonat W, Hilfrich J, et al. Improved Overall Survival in Postmenopausal Women With Early Breast Cancer After Anastrozole Initiated After 2 Years of Treatment With Tamoxifen Compared With Continued Tamoxifen: The ARNO 95 Study. J Clin Onc 2007 (Early online publication)




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