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First Study To Show Positive Benefit On Atherosclerosis For People,With Early Signs Of Diseased Arteries

hieved their LDL-C goal utilizing the 20mg dose of CRESTOR.

-Ends-
25 March 2007

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Notes To Editors
* People at low-risk of coronary heart disease as described in the METEOR study had a Framingham 10- year risk of less than 10 percent. The Framingham risk score is a method to determine an individual's risk of having either a fatal or non-fatal heart attack over the following 10 years. The risk score is based on an
individual's cholesterol level, blood pressure, smoking status, age and gender.

ASTEROID (A Study To Evaluate the Effect of Rosuvastatin On Intravascular Ultrasound-Derived Coronary Atheroma Burden) was a 104-week, open label, single-arm, blinded endpoint study designed to study the effect of CRESTOR 40mg in 507 patients who had undergone coronary angiography and who had evidence of coronary artery disease (CAD).
Key findings from ASTEROID include:

CRESTOR brought about a 0.79 per cent (median) reduction in percent atheroma volume in the entire target vessel (p<0.001) – first primary endpoint
CRESTOR brought about a 9.1 per cent (median) reduction in total atheroma volume in the most diseased 10mm segment of the target vessel (p<0.001) – second primary endpoint
CRESTOR brought about a 6.8 per cent (median) reduction in total atheroma volume in the entire target vessel (p<0.001) – secondary endpoint
These changes were associated with a 53 per cent reduction in LDL-C (p<0.001) and a 15% increase in HDL-C (p<0.001)
ORION (Outcome of Rosuvastatin Treatment on Carotid Artery Atheroma: a Magnetic Resonance Imaging ObservatioN) was the first study to
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