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First Controlled Large-Scale Intervention Angiotensin Receptor,Blocker (ARB) Trial in a Japanese Population, JIKEI HEART Study,Demonstrates Significant Reduction in Blood Pressure and Protection,of Organs with Valsartan

ypertension, ischemic heart disease or congestive heart failure. The primary endpoint was the onset of new or recurrent stroke, new or transient ischemic attack, hospitalization for congestive heart failure or angina pectoris, heart attack, aortic dissection, lower limb arterial obstruction, doubling of serum creatinine, or transition to dialysis. At the start of the clinical study, as well as during the course of the study, blood pressure and heart rate did not differ between the valsartan regime and the control regime.

The chief investigator was Seibu Mochizuki, M.D., PhD, Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, and the joint chief investigator was Bjorn Dahlof, Associate Professor, Department of Medicine, University of Goteborg Sahlgrenska University Hospital, Sweden.

The Jikei University School of Medicine

The Jikei University School of Medicine has its origins in the Sei-I-Kwai Koshujo (Medical Training School), the precursor to the University, which was founded in 1881 by Kenehiro Takaki. It is the oldest medical school in Japan. The Jikei University School of Medicine is currently positioned as one of the four educational institutions operated by the University, consisting of the Faculty of Medicine, the Medical Research department of the graduate school, four University hospitals, a clinic and the Research Center for Medical Sciences. At the four University hospitals there are approximately 2,600 beds and approximately 7,500 outpatients visit daily, making them the largest university hospitals in Japan.

In education, research and medical care, the Jikei University School of Medicine always adopts the founding spirit of Kanehiro Takaki of treating patients as human beings suffering from an illness, rather than examining them as research material. The University also devotes itself to the promotion of clinical research, of which Takaki is said to be the originator.

    
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