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Ferring Reports on ENDOMETRIN Presentations at Pacific Coast,Reproductive Society Annual Meeting

Progesterone Vaginal Supplement Studied in Largest-Ever IVF Trial in US

RANCHO MIRAGE, Calif., April 18, 2007 /PRNewswire/ -- Results of four studies evaluating Ferring Pharmaceuticals' ENDOMETRIN(R), a novel progesterone vaginal insert in development for luteal phase support (supplementation to provide support for implantation and the early stages of pregnancy) in assisted reproductive technologies (ART) were presented at the 55th Annual Meeting of the Pacific Coast Reproductive Society in Rancho Mirage, CA, April 18 to 22, 2007.

ENDOMETRIN is micronized progesterone in a tablet form that is vaginally inserted with a matched applicator. Marketing applications for ENDOMETRIN for luteal phase support in ART have been filed in the United States, Hong Kong and Israel.

"ENDOMETRIN was evaluated in the largest IVF trial ever undertaken in the United States across a wide range of patient types. Results from the trial show that ENDOMETRIN provided quality luteal phase support, measured by continuing pregnancy rates, and it is administered in an easy, patient- friendly way," said Kenneth B. Kashkin, M.D., Senior Vice President, Global Clinical Research and Development, Chief Medical Officer (U.S.), Ferring Pharmaceuticals. "Our studies also show that administering MENOPUR(R) and BRAVELLE(R) once a day in a single combined injection, another patient convenience, provided equivalent efficacy compared with twice-daily dosing, and excellent pregnancy rates."

Largest-Ever IVF Trial in the United States

The activity and tolerability of ENDOMETRIN were evaluated in a multicenter, randomized, open-label, assessor-blinded trial of 1,211 women, ages 18-42, undergoing in vitro fertilization (IVF). MENOPUR (menotropins for injection, USP) and BRAVELLE (urofollitropin for injection, purified), human- derived FSH, were used for the stimulation phase of IVF, with a minimum of one vial of MENOPUR per day. T
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