Navigation Links
Fat Kills Cancer: Turning Stem Cells from Fat Tissue into,Personalized, Cancer-Targeted Therapeutics

nsert the gene cytosine deaminase into the cell. This gene can convert a less toxic drug, 5-fluorocytosine (5-FC), to 5-FU inside the stem cells, and the chemotherapy can then seep out into the tumor, producing a lethal by-stander effect.

In nude mice – animals with an inhibited immune system – engrafted with human colon cancer, the researchers first injected the engineered mesenchymal stem cells, then 5-FC. They found tumor growth was inhibited by up to 68.5 percent in the animals, and none of the mice exhibited any signs of toxic side effects.

However, none of the animals remained tumor-free. “The procedure was quite effective even though we applied the stem cells just once. Obviously, repeated treatment will increase the efficacy, as would using this strategy in combination with other treatments,” Altaner said.

Normal mesenchymal cells can be isolated from various sources, including bone marrow, but the yield is not nearly as great as what the researchers derived from fat tissue. Removal of fat tissue during surgery to remove a tumor would be simple, says Altaner. Liposuction could also be used to isolate mesenchymal stem cells can also be gathered and isolated through liposuction, and the cells frozen in liquid nitrogen for future therapeutic use. Both processes would be easier than taking bone marrow from a patient, Altaner said.

The study was funded by grants from the Slovak Academy of Sciences and the League Against Cancer, and support from the Slovakian national cancer genomics program.

# # #

The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes nearly 26,000 basic, translational, and clinical researchers; health care professionals; an
'"/>




Page: 1 2 3

Related medicine technology :

1. News from the Battlefield of Metastatic Cancer: Epeius Biotechnologies Draws the Sword of Targeted Gene Delivery (Rexin-G) from the Stone of Chemistry and Physics
2. Prostate Cancer: Clinical Study Demonstrates Superior Efficacy of Docetaxel Chemotherapy
3. Beike Biotechnology Study Suggests Adult Stem Cells Show Promise for Peripheral Vascular Disease
4. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
5. In Vitro and In Vivo Data Show Alfacells Onocanse is Active Against Naive and Chemoresistant Neuroblastoma Cells
6. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
7. Publication Confirms that EpCAM, the Target for Two of Micromets Product Candidates, Is Overexpressed on Cancer Stem Cells of Certain Cancers
8. HepaLifes PBS-1 Cells for Influenza Vaccine Production Prove Superior at International Conference
9. Pluristems PLX Cells Demonstrate Potential to Treat Parkinsons Disease
10. Refrigerated Stem Cells Survive 12 Times Longer with ProtoKinetixs AAGP
11. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
Post Your Comments:
(Date:7/10/2014)... , July 10, 2014  BC Technical, the ... MiE America , Inc., a leading provider of ... into a long-term agreement naming BC Technical as the ... MiE and BC Technical announced today ... to establish BC Technical as the service and systems ...
(Date:7/10/2014)...   LabStyle Innovations Corp . (OTCQB:DRIO), developer of ... appointment of Professor Richard B. Stone ... Directors. Prof. Stone brings over forty-five ... as an entrepreneur, venture capitalist public, company officer ... He currently serves on the board of directors ...
(Date:1/15/2014)... /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from ... China,s orthopedic instrument industry has seen ... rising from 3.28 billion yuan in 2006 to 9.85 ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3
(Date:7/10/2014)... Oshkosh, Wisconsin (PRWEB) July 10, 2014 Ticketability.com ... There Tour,” and now Paul McCartney tickets for San Diego ... toured in San Diego since 1976, and the newly added ... from California fans. , Click Here to view ... tour tickets for Petco Park will become available to the ...
(Date:7/10/2014)... 10, 2014 One week ahead of ... Safety announced today it will extend compensation benefits to ... wages for workers displaced as a result of factory ... inspections have resulted in the closure of five factories ... cases, raising immediate safety concerns. In May, the Alliance—in ...
(Date:7/10/2014)... According to a new market research ... Airborne, Naval), Application (Software Defined Radios, SATCOM, Encryption, ... America, Asia-Pacific, Europe, the Middle East & ROW) ... the market is estimated to be $30.15 billion ... CAGR of 5.56% to reach $39.52 billion by ...
(Date:7/10/2014)... 2014 In his latest blog post ... treatment facility CEO Per Wickstrom has listed 5 ways ... to confirm an appointment, get information or sometimes even ... without being annoying is a skill that most people ... way to keep the dialogue moving without coming across ...
(Date:7/10/2014)... Creek, MI (PRWEB) July 10, 2014 ... alcohol treatment program that gets clients off to a ... recovery they can believe in, has launched a new ... , The new section highlights:, , ... Diagnostic and Statistic Manual of Mental Disorders (DSM-IV), including ...
Breaking Medicine News(10 mins):Health News:Paul McCartney Tickets for San Diego: Ticketability.com Announces Discounted Tickets for McCartney’s Tour Stop at Petco Park on September 28 2Health News:Alliance for Bangladesh Worker Safety to Double Compensation for Displaced Factory Workers; Members Vote to Extend Wage Benefits from Two to up to Four Months 2Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Per Wickstrom’s Latest Blog Post Lists 5 Ways to Follow-up Without Being Annoying 2Health News:Latest A Forever Recovery Launches Eating Disorders Section on Website 2
... Contract supports U.S. Army,s Stryker medical evacuation vehicle, ... AIRM ), the largest air medical transportation ... has been awarded a contract in,excess of $15 ... for Air Methods to provide more than 300 ...
... Oct. 27 New research published in the ... because the,fruit possesses antimicrobial phytochemicals that suppress growth ... gum disease. The study,was conducted at the College ... a research group led by Christine D. Wu, ...
... 6:00 am PST -- UCB announced,today the ... Research,and Education Foundation (REF) as a Pinnacle sponsor ... for Rheumatoid Arthritis." The,announcement was made at the ... are joining the Within Our Reach program because ...
... review finds it,s an accepted treatment in adults as ... -- Between 1990 and 2002, off-label use of anticancer ... and 33.2 percent, and most of that off-label use ... studies from a number of countries. , In off-label ...
... DALLAS, Oct. 27 From Illinois to California, ... (Connecting About,Real Experiences) to find out about patients, ... visit. Hospitals participating in the initial,launch of this ... IL;,Clovis Community Medical Center in Clovis, CA; HealthONE ...
... ARAY ), a global leader in the field ... present at the 19th,Annual Oppenheimer Healthcare Conference in New ... (7:00 a.m. PST.), A live webcast of the ... of the Company,s Web site at, http://www.accuray.com . The ...
Cached Medicine News:Health News:Air Methods Awarded $15 Million Contract From General Dynamics Land Systems 2Health News:University of Illinois - Chicago Study: Raisins Contain Compounds that May Inhibit Cavity-causing Bacteria 2Health News:UCB Becomes Pinnacle Donor to the American College of Rheumatology Research and Education Foundation's Research Campaign 2Health News:UCB Becomes Pinnacle Donor to the American College of Rheumatology Research and Education Foundation's Research Campaign 3Health News:Most Off-Label Cancer Drug Use for Palliative Care 2Health News:The Beryl Companies Launches CARE Calls Program in Five Hospitals Across U.S. 2Health News:Accuray Incorporated to Speak at Oppenheimer Healthcare Conference 2
... affordable, high-quality light guide cables work in ... provide optimal brightness during a number of ... give you the flexibility and ease-of-use necessary ... is fully-autoclavable so they can be easily ...
The Linvatec 3mm and 5mm Universal Light Guides are autoclavable. They offer flexibility, superior light transmission, and universal fittings in a lightweight package....
ACMI™ offers an assortment of fiberoptic light guides, high transmission autoclavable fiberoptic light guides, and light guide adapters to connect our scopes to other manufacturers' light sourc...
... Series Image Processing Video Camera is the ... specialties. This camera incorporates programmable head buttons ... enhancement, gain, and white balance to be ... and adjustable picture level control allow you ...
Medicine Products: