Navigation Links
Fat Kills Cancer: Turning Stem Cells from Fat Tissue into,Personalized, Cancer-Targeted Therapeutics

PHILADELPHIA, July 3, 2007 ? Researchers in Slovakia have been able to derive mesenchymal stem cells from human adipose, or fat, tissue and engineer them into “suicide genes” that seek out and destroy tumors like tiny homing missiles. This gene therapy approach is a novel way to attack small tumor metastases that evade current detection techniques and treatments, the researchers conclude in the July 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

“These fat-derived stem cells could be exploited for personalized cell-based therapeutics,” said the study’s lead investigator, Cestmir Altaner, Ph.D., D.Sc., an associate professor in the Cancer Research Institute of the Slovak Academy of Sciences in Bratislava. “Nearly everyone has some fat tissue they can spare, and this tissue could be a source of cells for cancer treatment that can be adapted into specific vehicles for drug transport.”

Mesenchymal stem cells help repair damaged tissue and organs by renewing injured cells. They are also found in the mass of normal cells that mix with cancer cells to make up a solid tumor. Researchers believe mesenchymal stem cells “see” a tumor as a damaged organ and migrate to it, and so might be utilized as a “vehicle” for treatment that can find both primary tumors and small metastases. These stem cells also have some plasticity, which means they can be converted by the micro environment of a given tissue into specialized cells, Altaner says.

After extracting the stem cells from human fat tissue the researchers worked to find a less toxic way to treat colon cancer than the standard-of-care chemotherapy agent, 5-fluorouracil (5-FU), which can produce toxic side effects in normal cells. They expanded the number of mesenchymal stem cells in the laboratory and then used a retrovirus vector to i nsert the gene cytosine deaminase into the cell. This gene can convert a less toxic drug, 5-fluorocytosine (5-FC), to 5-FU inside the stem cells, and the chemotherapy can then seep out into the tumor, producing a lethal by-stander effect.

In nude mice – animals with an inhibited immune system – engrafted with human colon cancer, the researchers first injected the engineered mesenchymal stem cells, then 5-FC. They found tumor growth was inhibited by up to 68.5 percent in the animals, and none of the mice exhibited any signs of toxic side effects.

However, none of the animals remained tumor-free. “The procedure was quite effective even though we applied the stem cells just once. Obviously, repeated treatment will increase the efficacy, as would using this strategy in combination with other treatments,” Altaner said.

Normal mesenchymal cells can be isolated from various sources, including bone marrow, but the yield is not nearly as great as what the researchers derived from fat tissue. Removal of fat tissue during surgery to remove a tumor would be simple, says Altaner. Liposuction could also be used to isolate mesenchymal stem cells can also be gathered and isolated through liposuction, and the cells frozen in liquid nitrogen for future therapeutic use. Both processes would be easier than taking bone marrow from a patient, Altaner said.

The study was funded by grants from the Slovak Academy of Sciences and the League Against Cancer, and support from the Slovakian national cancer genomics program.

# # #

The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes nearly 26,000 basic, translational, and clinical researchers; health care professionals; an d cancer survivors and advocates in the United States and more than 70 other countries. AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment, and patient care. AACR publishes five major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. Its most recent publication, CR, is a magazine for cancer survivors, patient advocates, their families, physicians, and scientists. It provides a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship, and advocacy.


American Association for Cancer Research
615 Chestnut St., 17th Floor
Philadelphia, PA 19106-4404

Telephone: (215) 440-9300
Toll Free Telephone: 1-866-423-3965
Fax: (215) 440-7228
E-mail: aacr@aacr.org


'"/>




Related medicine technology :

1. News from the Battlefield of Metastatic Cancer: Epeius Biotechnologies Draws the Sword of Targeted Gene Delivery (Rexin-G) from the Stone of Chemistry and Physics
2. Prostate Cancer: Clinical Study Demonstrates Superior Efficacy of Docetaxel Chemotherapy
3. Beike Biotechnology Study Suggests Adult Stem Cells Show Promise for Peripheral Vascular Disease
4. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
5. In Vitro and In Vivo Data Show Alfacells Onocanse is Active Against Naive and Chemoresistant Neuroblastoma Cells
6. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
7. Publication Confirms that EpCAM, the Target for Two of Micromets Product Candidates, Is Overexpressed on Cancer Stem Cells of Certain Cancers
8. HepaLifes PBS-1 Cells for Influenza Vaccine Production Prove Superior at International Conference
9. Pluristems PLX Cells Demonstrate Potential to Treat Parkinsons Disease
10. Refrigerated Stem Cells Survive 12 Times Longer with ProtoKinetixs AAGP
11. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/12/2019)... ... November 12, 2019 , ... MedMark Treatment Centers, a ... facility in the Cincinnati, OH suburb of Milford. MedMark Milford provides proven treatment ... clinic, located at 749C State Route 28 in Milford, is now accepting patients. ...
(Date:11/11/2019)... ... 11, 2019 , ... Oak Street Health , a network of primary ... centers in Greensboro and Charlotte, with an additional center in Charlotte under development. Committed ... model of care that emphasizes quality of care rather than quantity of services. Its ...
(Date:11/11/2019)... ... November 11, 2019 , ... MAPS and ... implementation of joint projects for the benefit of biomedical professionals in the ... professionals to leverage their roles in the research, development, and commercialization activities ...
Breaking Medicine Technology:
(Date:11/14/2019)... ... November 14, 2019 , ... BioInformatics Inc., part of Science and Medicine Group, ... that 7 companies have been nominated for a Life Science Industry Award ... the Life Science Industry Awards have recognized manufacturers of the “tools of science” that ...
(Date:11/12/2019)... ... ... AI for preventable harm analytics leader Jvion today announced that Jvion was included ... AI”, which provides a “tip of the spear” analysis of the healthcare AI market. ... complete a full KLAS analysis, Jvion was featured as having “by far the largest ...
(Date:11/12/2019)... , ... November 12, 2019 , ... ... and compliance management, today announced the release of new features for custom branding. ... platform interface and emails to match their physical brand attributes. Customizable attributes include ...
(Date:11/11/2019)... ... November 11, 2019 , ... Last year’s expo was a resounding success ... box buyers like Costco, Walmart, and GNC. Exhibitors included some of the biggest ... , This year, CBD.io and partners, are once again set to ...
(Date:11/9/2019)... ... November 08, 2019 , ... The Women’s Dermatologic Society (WDS) ... health concerns. The WDS Board of Directors appointed Molly Hinshaw, MD to fill the ... current March 2019-March 2020 term and will be presented to the membership as the ...
Breaking Medicine News(10 mins):