( higher dosages. IL-12 plasmid was dete...)Expression Genetics, Inc. Announces Successful Completion of Phase,I Trial of Gene-Based IL-12 for Treatment of Ovarian Cancer,Health

higher dosages. IL-12 plasmid was detectable in peritoneal fluid of all evaluable patients and in blood samples of only a few patients at considerably lower level, suggesting that the plasmid delivery following EGEN-001 administration was localized at the delivery site, a major advantage of EGEN-001 therapy over recombinant protein therapy. The IP administered EGEN-001 was biologically active since it increased the peritoneal levels of interferon-gamma, the predominant cytokine activated by IL-12, in all patients.

"We are quite pleased with the safety profile of EGEN-001 observed in this initial clinical trial and are encouraged by some of the preliminary efficacy and activity results we have seen resulting from the administration of EGEN- 001 monotherapy in advanced ovarian cancer patients," said Dr. Danny H. Lewis, CEO of Expression Genetics. "We have completed the necessary regulatory process and expect to immediately begin enrollment of patients in our next study which will combine EGEN-001 administration with conventional chemotherapy in platinum-sensitive recurrent ovarian cancer patients."

The lead investigator, Ronald Alvarez, M. D., Director of Gynecologic Oncology, The University of Alabama at Birmingham, stated, "We are encouraged by the initial clinical results of this trial and look forward to moving ahead with expanded clinical testing of EGEN-001 in order to evaluate the safety of this experimental drug in combination with paclitaxel and platinum based chemotherapy treatment regimens."

About Ovarian Cancer

Ovarian cancer accounts for approximately 4 percent of all women's cancers and is the fourth leading cause of cancer-related death among women in the U.S. The American Cancer Society statistics for ovarian cancer estimate that there will be 22,430 new cases and 15,280 deaths in 2007. The death rate for this disease has not changed much in the last 50 years. Ovarian cancer has the highest mortality of all cancers of the f
'"/>

Page: 1 2 3 4
Related medicine technology :

1. Inovio Biomedicals DNA Delivery Technology Shows Safety and Enhances Gene Expression & Tumor Responses in Interim Melanoma Clinical Study Results
2. Abraxis BioScience Presents Pre-Clinical Findings That Support Role of SPARC Expression in Cancer and the Role of the Nanoparticle Albumin Bound (nab) Technology Platform in Targeting the Pathway
3. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
4. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
7. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
8. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
9. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
10. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
11. Protox Announces Positive Clinical Data from Prostate Cancer Study