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Everest Data on Short- and Long-Term Use of Otsuka's,Investigational Novel Treatment, Tolvaptan, Published in Journal of,the American Medical Association and Featured in ACC's Late,Breaking Clinical Trials

) SHAPE Survey Results to the General Public, Annual Congress of the European Society of Cardiology in Vienna, September 2003. (7) ACC News Release, " of Cardiology / American Heart Association guidelines: New heart failure guidelines stress early

diagnosis and treatment," August 16, 2005. Accessed at http://www.acc.org/media/releases/highlights/2005/aug05/hf%5Fguideline%5Fupdat e.htm on March 1, 2007.

CONTACT: Debra Kaufmann, Otsuka America Pharmaceutical, Inc.,+1.240.683.3568, debra.kaufmann@otsuka.com

Web site: http://www.otsuka.com/

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