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Everest Data on Short- and Long-Term Use of Otsuka's,Investigational Novel Treatment, Tolvaptan, Published in Journal of,the American Medical Association and Featured in ACC's Late,Breaking Clinical Trials

al., "Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure: The EVEREST Outcome Trial." JAMA 2007;297:1319- 1331.

Gheorghiade, M, et al., "Short-Term Clinical Effects of Tolvaptan, an Oral Vasopressin Antagonist, in Patients Hospitalized for Heart Failure: The EVEREST Clinical Status Trials." JAMA 2007;297:1332-1343.

ACC Presentation: 402-7

Session: ACC.07 Late-Breaking Clinical Trials I, Sunday, Mar 25, 2007, 8:30 AM -10:00 AM CST. Presentation Start Time: Sunday, Mar 25, 2007, 8:50 AM CST Effects of Vasopressin Receptor Antagonism With Tolvaptan on Clinical Status, Morbidity and Mortality in Patients Hospitalized With Acute Decompensated Heart Failure: Results of the EVEREST Trial Marvin A. Konstam, Mihai Gheorghiade, John C. Burnett, Jr., Liliana Grinfeld, Aldo P. Maggioni, Karl Swedberg, Faiez Zannad, James E. Udelson, Christopher A. Zimmer, Cesare Orlandi for the EVEREST Investigators.

    (1) Gheorghiade M, Konstam MA, Burnett JC, et al. Short-Term Clinical

        Effects of Tolvaptan, an Oral Vasopressin Antagonist, in Patients

        Hospitalized for Heart Failure:  The EVEREST Clinical Status Trials.

        JAMA. 2007;297:1332-1343.


    (2) Konstam MA, Burnett JC, Gheorghiade M, et al. Effects of Oral

        Tolvaptan in Patients Hospitalized for Worsening Heart Failure:  The

        EVEREST Outcome Trial. JAMA. 2007;297:1319-1331.


    (3) Rosamond W, Flegal K, Friday G, et al; Heart Disease and Stroke

        Statistics - 2007 Update A Report From the American Heart Association

        Statistics Committee and Stroke Statistics Subcommittee. Circulation.

        2007;115:e69-e171.


    (4) Press Release.  "FDA Approves Astellas' VAPRISOL(R) For The Treatment

        Of Euvolemic Hyponatremia."  Astellas, December 30, 2005.


    (5) Verbalis JG. AVP Receptor Antagonists as Aquaretics: Review and

        Assessment of Clinical Data. Cleveland Clinic J Med 2006;73(3):S24-33.


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