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Eurand's Zentase Effective in Treating Exocrine Pancreatic,Insufficiency, Studies Show

1.82 at screening and 1.45 stools during treatment (p<0.001). The mean proportion of oily stools was 11.1 percent at screening and 4.73 percent during treatment (p<0.001). -- Improved EPI Signs and Symptoms. During Zentase treatment 37 percent of patients were characterized as improved by physicians and 47 percent were characterized as improved by parents, as compared to previous therapy. No patients were characterized as worsened on treatment with Zentase. -- Well Tolerated. There were minimal AEs, none of which led to discontinuation or study drug interruption. One serious AE was considered unrelated to study drug and resolved without discontinuation. The most commonly reported AEs were abdominal pain, steatorrhea, discolored feces, flatulence and vomiting.

Zentase Stability on Food

With very young children with EPI, it is common practice to sprinkle the enzymes on a small amount of food, for example, on applesauce. Studies of 11 different baby and infant foods, including applesauce, evaluated which other foods were suitable for sprinkling with Zentase.

The study showed that Zentase could remain for . 1 hour without any significant deterioration of the enteric coating when sprinkled on the majority (10/11) of tested foods. Thus, with its enteric coating fully intact, even after an hour on food, Zentase remains protected from the harsh, acidic environment of the stomach and is released only when the enzymes reach the upper gastrointestinal tract - where the enzymes are needed for proper digestion of food. This study provides parents with a wider selection of foods to use in giving enzymes to their children when applesauce is not an option or when children want variety.

About Zentase

Zentase was designed to meet the US Food and Drug Administration (FDA) guidelines for PEPs(2). PEPs have been used since before the enactment of the U
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