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Enzo Biochem Individualized Oral Immune Regulation Therapy May Be,Effective Approach to Treating Crohn's Disease

, subjects received a regimen of 3 weekly doses for 15 weeks of either active treatment or placebo; in the other trial, all subjects received placebo for 3 weeks and then 12 weeks of either active treatment or placebo. Forty subjects were evaluated for an additional 6 weeks after the treatment period.

Outcome measures included clinical remission and response measured by CDAI score, quality of life measured using the Inflammatory Bowel Disease Questionnaire (IBDQ), and investigation of a number of potential surrogate biomarkers. Rates of remission and response nearly doubled for evaluable subjects treated with Alequel(TM) compared to placebo, although, due to the size of the studies, the differences were not yet statistically significant. Enzo is currently enrolling additional patients in the trials. Mean percent change in IBDQ quality-of-life score was 3 times greater for patients treated with Alequel(TM) compared to placebo. Treatment was well tolerated, with no treatment-related adverse events reported.

About Crohn's disease (CD)

CD is an idiopathic, immune-mediated disorder currently believed to result from a cascade of processes initiated by unidentified antigens. This inflammatory disease of the GI tract affects approximately 500,000 people in the United States and at least that many in the rest of the world. The disease is characterized by flare-ups of symptoms such as diarrhea, abdominal pain, rectal bleeding and loss of appetite, alternating with periods of remission. Systemic complications of chronic disease include weight loss, anemia and increased risk of bowel cancer.

About Enzo

In addition to Alequel, Enzo Therapeutics is developing therapies for HIV/AIDS and non alcoholic steatohepatitis (NASH) and uveitis, as well as conducting pre-clinical research on candidate therapies for osteoporosis and fractures, among other applications. Enzo Biochem is engaged in the research, development and manufacture of innovative health
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