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Enzo Biochem Individualized Oral Immune Regulation Therapy May Be,Effective Approach to Treating Crohn's Disease

WASHINGTON--(BUSINESS WIRE)--May 22, 2007 - Alequel(TM), an individualized oral immune regulation preparation, may be an effective treatment for moderate-to-severe Crohn's disease. Interim data from two ongoing double-blind, placebo controlled Phase II studies suggest that this investigational approach induced good clinical remissions and improved patients' quality of life compared to placebo. Medical researchers from Hebrew University-Hadassah Medical Center, Jerusalem, Israel, will today present clinical trial results at Digestive Disease Week 2007, the largest international gathering of academic researchers and practicing physicians in gastrointestinal (GI) specialties, held this year in Washington, DC. The trials were sponsored by Enzo Therapeutics, Inc., a wholly owned subsidiary of Enzo Biochem, Inc. (NYSE:ENZ).

"Given our current understanding of Crohn's disease as an inappropriate autoimmune response in the GI tract, we are developing Alequel as an individualized oral treatment that harnesses the patient's own immune system to alleviate symptoms," said Gary C. Cupit, PharmD, President of Enzo Therapeutics. "Many Crohn's patients are frustrated with current treatment options; Alequel is designed to reduce patients' dependence on systemic immunosuppressant drugs. The interim Phase II results encourage us to advance beyond these two studies presented this week at DDW. Thus, we are planning to expand into more advanced studies in the United States."

About the Clinical Studies

These two double-blind, placebo-controlled studies randomized 49 subjects with moderate-to-severe Crohn's disease as measured by the Crohn's Disease Activity Index (CDAI). Alequel(TM) therapy consists of oral administration of an autologous protein-containing extract, individually prepared from mucosal tissue colon biopsies of the subject obtained through colonoscopy (a common procedure for Crohn's patients). In one trial
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