Navigation Links
Enzo Biochem Individualized Oral Immune Regulation Therapy May Be,Effective Approach to Treating Crohn's Disease

WASHINGTON--(BUSINESS WIRE)--May 22, 2007 - Alequel(TM), an individualized oral immune regulation preparation, may be an effective treatment for moderate-to-severe Crohn's disease. Interim data from two ongoing double-blind, placebo controlled Phase II studies suggest that this investigational approach induced good clinical remissions and improved patients' quality of life compared to placebo. Medical researchers from Hebrew University-Hadassah Medical Center, Jerusalem, Israel, will today present clinical trial results at Digestive Disease Week 2007, the largest international gathering of academic researchers and practicing physicians in gastrointestinal (GI) specialties, held this year in Washington, DC. The trials were sponsored by Enzo Therapeutics, Inc., a wholly owned subsidiary of Enzo Biochem, Inc. (NYSE:ENZ).

"Given our current understanding of Crohn's disease as an inappropriate autoimmune response in the GI tract, we are developing Alequel as an individualized oral treatment that harnesses the patient's own immune system to alleviate symptoms," said Gary C. Cupit, PharmD, President of Enzo Therapeutics. "Many Crohn's patients are frustrated with current treatment options; Alequel is designed to reduce patients' dependence on systemic immunosuppressant drugs. The interim Phase II results encourage us to advance beyond these two studies presented this week at DDW. Thus, we are planning to expand into more advanced studies in the United States."

About the Clinical Studies

These two double-blind, placebo-controlled studies randomized 49 subjects with moderate-to-severe Crohn's disease as measured by the Crohn's Disease Activity Index (CDAI). Alequel(TM) therapy consists of oral administration of an autologous protein-containing extract, individually prepared from mucosal tissue colon biopsies of the subject obtained through colonoscopy (a common procedure for Crohn's patients). In one trial
'"/>




Page: 1 2 3

Related medicine technology :

1. Researchers Discover Method for Identifying How Cancer Evades the Immune System
2. Research Indicates Gerons Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System
3. Lexicon Pharmaceuticals and Fox Chase Publish Findings on Immune Deficiency
4. Cervarix, the GSK Cervical Cancer Candidate Vaccine, Provides Sustained Immune Response in 100 Percent of Women up to 55 Years of Age
5. Infinity and MedImmune Present Updated Phase I Results of IPI-504 in GIST at ASCO Annual Meeting
6. CytImmune Presents Positive CYT-6019 Data During the American Society of Clinical Oncology Annual Meeting in Chicago
7. Infinity and MedImmune Announce Updated Data On Ipi-504 to be Presented At ASCO
8. MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations
9. CEL-SCIS CEL-1000 Shown to Significantly Enhance Immune Response Against Avian Flu Antigen in Animals
10. VGX Pharmaceuticals Novel HIV and Pandemic Influenza DNA Vaccine Candidates Trigger Robust Immune Responses and Protection in Pre-Clinical Models
11. MedImmune Announces Positive Clinical Results at PAS Annual Meeting From Large Prospective Trial in Prevention of Serious RSV Disease
Post Your Comments:
(Date:12/19/2014)... 18, 2014 Research and Markets ... the "Micro Market Monitor: North American Dermatology ... http://photos.prnewswire.com/prnh/20130307/600769 ... steadily, which has resulted in fueling the overall ... main purpose of these dermatology devices is to ...
(Date:12/19/2014)... -- Capnia, Inc. (NASDAQ: CAPN ), ... on its proprietary Sensalyze™ Technology Platform for precision ... for the third quarter and nine months ended ... of our initial public offering (IPO), we are ... CoSense® commercial launch," said Anish Bhatnagar, M.D., Chief ...
(Date:12/19/2014)... , Dec. 18, 2014 Since last ... the site now known as the leading online black ... seen explosive growth in its offering of drugs and ... Alliance show the takedowns did succeed in lowering the ... last review of the markets in August. But some ...
Breaking Medicine Technology:Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3
... Mass., May 9, 2011 Boston Scientific Corporation (NYSE: ... international launch of its Expect™ Endoscopic Ultrasound Aspiration Needle, ... malignancies in organs adjacent to the gastrointestinal tract.  The ... earlier this year and is being marketed in the ...
... Avanir Pharmaceuticals, Inc. (NASDAQ: AVNR ... the position of vice president of legal affairs. ... stage biopharmaceutical company, Elona,s legal, regulatory and business expertise will ... Katkin, president and CEO of Avanir. "The executive team and ...
Cached Medicine Technology:Boston Scientific Begins U.S. and International Launch of Expect™ Endoscopic Ultrasound Aspiration Needle 2Boston Scientific Begins U.S. and International Launch of Expect™ Endoscopic Ultrasound Aspiration Needle 3Boston Scientific Begins U.S. and International Launch of Expect™ Endoscopic Ultrasound Aspiration Needle 4Avanir Pharmaceuticals Announces Appointment of Elona Kogan, Esq. as Vice President of Legal Affairs 2
(Date:12/19/2014)... 18, 2014 (HealthDay News) -- A new study suggests ... to severe hot flashes and night sweats -- and ... Hot flashes are common during menopause, affecting about 60 ... affect women after menopause, since they then face a ... findings suggest women who exhibit moderate or severe menopausal ...
(Date:12/19/2014)... 2014 (HealthDay News) -- Traveling through the same U.S. ... to three others within a four-hour time span, illustrating ... report shows. "The exposures in this report were ... an international terminal, highlighting the fact that measles is ... an infectious disease specialist at the U.S. Centers for ...
(Date:12/17/2014)... Dr. Myo Nwe is the co-author of a ... Future” and co-founder of the Ace Medical Weight Loss Center ... a broad look at the industry of weight loss, and ... On film and in television shows, however, she says the ... aspects and played for basic laughs, which she believes impacts ...
(Date:12/17/2014)... CA (PRWEB) December 17, 2014 A group ... Center for Longevity, today, in reaction to a recent statement ... science of brain training and derogated the efficacy of all ... they agreed with the parts of the center’s statement critical ... believed the center had also overstated its case, in a ...
(Date:12/17/2014)... December 17, 2014 Project Veritas is ... brought videos of MIT economist and Obamacare architect Jonathan ... James O’Keefe conducted the interview, which is being distributed ... there was intentional mislabeling in the Affordable Care Act ... bill: A two-hundred-and-fifty billion dollar per year tax grab. ...
Breaking Medicine News(10 mins):Health News:Severe Hot Flashes During Menopause May Raise Hip Fracture Risk Later: Study 2Health News:Arriving Now at Gate 42: Measles 2Health News:Arriving Now at Gate 42: Measles 3Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 3Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 4Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2
... activity, and it is the kind of music but the ... ,The findings, published ahead of print in Heart, are based ... men and women, taken before and while they listened to ... were trained musicians, who had been playing instruments for at ...
... to provide protection against lung cancer, according to the ... be responsible are plant-derived compounds known as phytoestrogens found ... fruits and vegetables, the report from the University of ... compounds have been shown to have a protective effect ...
... protein has helped bald mice to get fur on the ... men., ,Catherine C. Thompson and colleagues at Johns Hopkins ... as Hairless, which encodes a protein that is essential for ... mutations in the Hairless gene, hair growth is initially normal. ...
... Anbumani Ramadoss today fired another salvo at Medical Council of India ... of mafias over such a regulatory body was // a ... body and the government has no say in its functioning. What ... ,He said a cleansing process of the councils was ...
... living with HIV/AIDS in Manipur have hope at hand ... specialised clinics for their care and treatment//.,The Nobel prize-winning ... signed a memorandum of understanding with the Manipur government ... HIV/AIDS. ,The Dutch chapter of the MSF ...
... suffer from osteoporosis from loss of bone mass, there may ... shows that it can help improve bone mass in women ... of the principal recommendations for preventing and treating the loss ... isn’t always possible, particularly for the frail., ,An experimental ...
Cached Medicine News:Health News:Taking Music Lesson To Reduce Stress 2Health News:Specialized Clinics For Manipur's AIDS Patients 2
... Medtronic Ophthalmics offers the most comprehensive ... Eraser Instruments for Cataract incision, Glaucoma ... discrete coagulation is achieved with minimal ... necrosis. Straight eraser styles are available ...
... Centuries of German Craftsmanship have ... in the world. Ocutek now ... Only holders of the coveted ... eight-year apprenticeship, are qualified to ...
... Centuries of German Craftsmanship ... instrumentation in the world. Ocutek ... you! Only holders of the ... and eight-year apprenticeship, are qualified ...
... Centuries of German Craftsmanship ... instrumentation in the world. Ocutek ... you! Only holders of the ... and eight-year apprenticeship, are qualified ...
Medicine Products: