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EntreMed Presents Preclinical Data for MKC-1 in Hematological,Cancers

ally in an AML cell line. MKC-1, therefore, induces apoptosis in hematopoietic cell lines and patient samples through a complex mechanism involving arrest of the cell cycle and disruption of multiple oncogenic survival pathways.

Mark R. Bray, Ph.D., EntreMed's Vice President Research, commented on the results, "These data provide further evidence that MKC-1 disrupts multiple survival pathways in tumor cells, including the PI3-Kinase and mTOR signaling pathways. Our results indicate that MKC-1 causes cell cycle arrest and induces apoptosis both in leukemia cell lines and in leukemia patient samples."

Dr. Bray also commented, "These findings further support our plans to evaluate MKC-1 in leukemia patients, either as a single agent or in combination with other chemotherapeutic agents. MKC-1 is currently in Phase 2 trials for metastatic breast cancer and non-small cell lung cancer, as well as a Phase 1 clinical trial for leukemia. We plan to continue evaluating the clinical potential for MKC-1 in both solid and hematological tumors."

To view the poster presentation, visit Scientific Presentations under the Therapeutic Pathways section of the Company's web site at www.entremed.com.

About EntreMed

EntreMed, Inc. is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation. Panzem(R) (2-methoxyestradiol or 2ME2), the Company's lead drug candidate, is currently in Phase 2 clinical trials for cancer, as well as in preclinical development for rheumatoid arthritis. MKC-1, an oral cell cycle regulator, is in Phase 2 studies for cancer. ENMD-1198, a novel tubulin binding agent, is also in Phase 1 studies in advanced cancers. EntreMed's goal is to develop and commercialize new compounds based on the Company's expertise in angiogenesis, cell cycle regulation and inflammation -- processes vital to the treatment of cancer a
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