Navigation Links
EntreMed Presents Preclinical Data for MKC-1 in Hematological,Cancers

ROCKVILLE, Md., April 19, 2007 /PRNewswire-FirstCall/-- EntreMed, Inc. , a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the presentation of preclinical results for MKC-1, its novel cell cycle inhibitor. The data were presented by EntreMed scientists at the American Association for Cancer Research (AACR) Annual Meeting being held this week in Los Angeles, California.

MKC-1 is a novel, orally-active cell cycle inhibitor with in vitro and in vivo efficacy against a broad range of human solid tumor cell lines, including multi-drug resistant cell lines. In previous studies, MKC-1 demonstrated broad-acting antitumor effects, showing tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. These effects are consistent with mechanisms resulting from MKC-1 binding to multiple intracellular targets, including tubulin and the importin-beta proteins. The importin-beta family of proteins plays a critical role in nuclear transport and cell division.

In these studies, MKC-1 showed potent, dose-dependent activity against a variety of cell lines derived from cancers of human blood cells, and inhibited growth of primary cells derived from acute and chronic myelogenous leukemia (AML and CML) patients in vitro. MKC-1 was also shown to inhibit PI3-Kinase and mTOR pathways by inducing a dose-dependent reduction in the levels of the activated forms of the oncogenic kinases Akt and p70S6K. These signaling pathways are strongly linked to cancer proliferation and survival.

Additionally, MKC-1 showed enhanced activity with cytosine arabinoside (Ara-C) in combination studies in vitro when added either simultaneously or sequenti
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Clinical Results From EntreMeds Panzem NCD and Taxol Breast Cancer Study Presented at ASCO
2. Phase 2 Results for EntreMeds Panzem NCD Brain Cancer Study Presented at ASCO
3. EntreMeds Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models
4. EntreMed Presents Multi-Mechanism Results for ENMD-1198 at AACR Annual Meeting
5. EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models
6. EntreMed Presents Mechanism Data for Its Three Lead Oncology Compounds
7. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
8. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
9. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
10. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
11. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
Post Your Comments:
(Date:8/22/2014)... MC Medical, a subsidiary of Mitsubishi Corporation (MCM), and Minimally ... medical device company, have formally agreed to an exclusive ... in Japan . It is anticipated that ... in the latter half of 2015. ... in endoscopic surgery market in Japan . ...
(Date:8/22/2014)...  Mark Riccio, director of Cornell University,s multi-scale ... the online crowd-funding platform Kickstarter to bring non-invasive ... and would-be superheros everywhere: "for FREE." Riccio,s campaign, ... if you had Superman,s X-ray vision?" The campaign ... from elementary through high school students, academic institutions, ...
(Date:8/22/2014)... 22, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today ... units of common stock and warrants at a price ... million, prior to deducting underwriting discounts and commissions and ... warrants are immediately separable and will be issued separately.  ... trading on The NASDAQ Stock Market under the ticker ...
Breaking Medicine Technology:MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2Cornell's X-ray Imaging Lab Director Uses Kickstarter Campaign to "Democratize" Advanced 3D Imaging 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4
... Systems, Inc. , the maker of TrackWise ... in enterprise quality and compliance management solutions, today ... provider of high-quality generic pharmaceuticals, has selected TrackWise® ...   As the manufacturer of more ...
... for Full Year Fiscal 2010 -- WEIFANG, China, Sept. 29 /PRNewswire-Asia-FirstCall/ -- ... ... ... ,; var first_result; // Results are keyed by longUrl, so we need to grab the first one. ...
Cached Medicine Technology:Qualitest Pharmaceuticals Selects TrackWise® for Comprehensive Enterprise Quality and Document Management 2Qualitest Pharmaceuticals Selects TrackWise® for Comprehensive Enterprise Quality and Document Management 3Qualitest Pharmaceuticals Selects TrackWise® for Comprehensive Enterprise Quality and Document Management 4Shengtai Pharmaceutical Reports Financial Results for Full Year Fiscal 2010 2Shengtai Pharmaceutical Reports Financial Results for Full Year Fiscal 2010 3Shengtai Pharmaceutical Reports Financial Results for Full Year Fiscal 2010 4Shengtai Pharmaceutical Reports Financial Results for Full Year Fiscal 2010 5Shengtai Pharmaceutical Reports Financial Results for Full Year Fiscal 2010 6Shengtai Pharmaceutical Reports Financial Results for Full Year Fiscal 2010 7Shengtai Pharmaceutical Reports Financial Results for Full Year Fiscal 2010 8Shengtai Pharmaceutical Reports Financial Results for Full Year Fiscal 2010 9
(Date:8/22/2014)... August 22, 2014 Menstrual leaks risk ... from Sunrise, Fla., decided that there needed to be ... to use and producible in design variations, the Safety ... by leaks, which avoids embarrassment and promotes peace of ... sanitary pads. , The original design was submitted to ...
(Date:8/22/2014)... News) -- Counseling may do little to help young ... Researchers analyzed 66 studies that included nearly 18,000 people ... risk for drinking problems. Participants in 49 studies attended ... rest of the studies attended group sessions or a ... technique called motivational interviewing was used in the studies. ...
(Date:8/22/2014)... News) -- College can be a challenging time for young ... do to make the most of their new life, an ... meet new people and learn to manage the temptations of ... assessment at St. John,s University in New York City, said ... place in the classroom. College is a time when students ...
(Date:8/22/2014)... with severe disabilities and multiple chronic conditions are screened ... disabilities or no chronic conditions, a new study has ... women with moderate disabilities or women with only one ... scientist with the Li Ka Shing Knowledge Institute of ... disabilities often have other measures of social vulnerability, such ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Ticket Down ... tickets in Kalamazoo, New Orleans, Albuquerque and Rapid City. ... the “Long Island Medium,” Theresa Caputo, allows just that. Caputo ... She is part of a close knit family who began ... with a spiritual healer, realized she had a chance to ...
Breaking Medicine News(10 mins):Health News:Counseling Does Little to Deter Youth Drinking, Review Finds 2Health News:College Prep 101 2Health News:Women with severe, chronic health issues are screened for breast cancer less often 2Health News:Theresa Caputo Tickets in Kalamazoo at Wings Stadium, Saenger Theatre in New Orleans, Kiva Auditorium in Albuquerque and Rapid City at Don Barnett Arena Now Available 2
... Champions Gupta,s Commitment to Enriching Quality of Life Through ... American Council on Exercise (ACE), America,s leading authority on ... and training organizations in the world, today announced its ... , chief medical correspondent for the health and medical ...
... Emerson Network Power, a business of Emerson and the global ... its DA12-M series wall mount switching adapters, designed specifically for ... ... Carlsbad, CA (PRWEB) January 27, 2009 -- ...
... Consultants announced today,that its annual long-term care insurance training ... TN. , "This is THE ... is,100% sales training from the nation,s leading LTCI sales ... VP of Marketing. "The,primary focus of this seminar ...
... San Antonio -- The University of Texas at San ... status. UTSA,s College of Engineering has been awarded a ... to study energy combustion. , "This is one of ... study clean combustion, gasification and energy efficiency," said Efstathios ...
... CORONA DEL MAR, Calif., Jan. 27 Dr. ... technique in 1992 and has been successfully educating ... since. Dr. Friedberg has received a Congressional award ... the U.S. military in Iraq and Afghanistan. Benefits: ...
... real cost of the procedure beyond the initial price of surgery. ... of choosing a cosmetic surgeon wisely based on credentials, certification, and understanding, ... ... 2009 - You may be under the mistaken notion that because breast ...
Cached Medicine News:Health News:American Council on Exercise (ACE) Endorses Appointment of Dr. Sanjay Gupta as Surgeon General of the United States 2Health News:Emerson Network Power Introduces High Density AC-DC Adapters for Medical Applications 2Health News:Emerson Network Power Introduces High Density AC-DC Adapters for Medical Applications 3Health News:Phyllis Shelton's LTCI Sales Skills Seminar a Must-Attend Event for Insurance Professionals 2Health News:UTSA receives federal funding for fossil fuel research 2Health News:Cosmetic Surgery - PK 'Goldilocks' Anesthesia: All of the Benefits, None of the Risks 2Health News:Interested in Breast Augmentation, New Jersey? Be Sure You Know the “Real Cost” 2Health News:Interested in Breast Augmentation, New Jersey? Be Sure You Know the “Real Cost” 3Health News:Interested in Breast Augmentation, New Jersey? Be Sure You Know the “Real Cost” 4
Straight shafts with heavy Elschnig teeth. Flat serrated handle with slide style lock and polished finished....
Straight shafts with fine Pierse type tips. Flat smooth handle with dull finish....
Straight shafts with delicate 0.7 mm, 1 x 2 teeth. Serrated handle with polished finish....
Straight shafts with 1 x 2 Elsching style teeth. Wide serrated handle with polished finish....
Medicine Products: