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EntreMed Presents Multi-Mechanism Results for ENMD-1198 at AACR,Annual Meeting

tubule destabilizing agent) sensitive and resistant leukemia cell lines. Results from in vivo studies also showed that treatment with ENMD-1198 prolonged survival rates significantly in vinca alkaloid sensitive and resistant (ALL3, ALL7 and ALL19) preclinical leukemia models.

"These data further support ENMD-1198's potential for broad application in a variety of solid and hematological cancers," said Carolyn F. Sidor, M.D., M.B.A., EntreMed's Vice President and Chief Medical Officer. "Preclinical studies with ENMD-1198 continue to highlight its significant antitumor activity and multiple mechanisms of action. These studies will help guide our selection of indications for further clinical development. ENMD-1198 is currently in a Phase 1 dose-escalation study in advanced cancer patients, and we anticipate presentation of interim clinical data from the Phase 1 study later this year."

To view the poster presentations, visit Scientific Presentations under the Therapeutic Pathways section of the Company's web site at http://www.entremed.com.

About EntreMed

EntreMed, Inc. is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation. Panzem(R) (2-methoxyestradiol or 2ME2), the Company's lead drug candidate, is currently in Phase 2 clinical trials for cancer, as well as in preclinical development for rheumatoid arthritis. MKC-1, an oral cell cycle regulator, is in Phase 2 studies for cancer. ENMD-1198, a novel tubulin binding agent, is also in Phase 1 studies in advanced cancers. EntreMed's goal is to develop and commercialize new compounds based on the Company's expertise in angiogenesis, cell cycle regulation and inflammation -- processes vital to the treatment of cancer and other diseases, such as rheumatoid arthritis. Additional information about EntreMed is available on the Company's website at '"/>




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