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EntreMed Presents Mechanism Data for Its Three Lead Oncology,Compounds

composed of dimeric tubulin proteins. Microtubule targeting drugs are one of the most successful classes of chemotherapy agents and are used for both solid and liquid tumors. There are three drug binding sites on tubulin: the vinca binding domain, the taxol- binding site and colchicine-binding site. The vinca alkaloids destabilize microtubules. The taxanes bind to the taxol-binding site and stabilize microtubules. While vincas and taxanes are widely used for treating cancer, there is a need to develop orally available molecules that have reduced toxicity and overcome resistance to approved chemotherapeutic agents.

Carolyn F. Sidor, M.D., M.B.A., EntreMed Vice President and Chief Medical Officer, commented on the results, "EntreMed is focused on developing multi- mechanism drugs for the treatment of cancer that have both antiproliferative and antiangiogenic properties. Tubulin binding and subsequent microtubule disruption are common mechanisms of our three lead compounds, yet clinical and preclinical data for these product candidates demonstrate that subtle differences in microtubule dynamics can lead to different approaches to the treatment of cancer. Panzem(R), MKC-1 and ENMD-1198 are all orally-active yet distinct tubulin binding agents, and exhibit a different array of antitumor activity preclinically. Understanding the multiple mechanisms of these drug candidates will help guide our selection of clinical indications and biomarkers. Panzem(R) NCD and MKC-1 are currently in multiple Phase 2 clinical trials for cancer and ENMD-1198 is in Phase 1 trials in advanced cancer patients."

To view the presentation, visit Scientific Presentations under the Therapeutic Pathways section of the Company's web site at http://www.entremed.com.

About EntreMed

EntreMed, Inc. is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflam
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