Navigation Links
Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery,of GLP-1 and PYY

the 4 mg oral dose of GLP-1 was 300 pMol/L.

In the PYY study, the drug was given orally to six healthy male subjects in a six way cross-over design. The treatment arms consisted of oral doses (0.25, 0.5, 1.0, 2.0 and 4.0 mg) of PYY with Emisphere's delivery agent administered as a single tablet versus placebo. The Cmax value of PYY for the 4 mg oral dose had a plasma concentration of 629 pg/ml. In addition, there was a reduction of Ghrelin in all groups administered PYY with the largest percent reduction in Ghrelin levels observed in the 4 mg PYY dose.

"This study showed for the first time that GLP-1 was active with regard to stimulation of insulin releases in humans after oral administration. In the subjects receiving the highest doses of oral GLP-1, we observed nausea effects similar to those seen when the subjects received high levels of injectable GLP-1. The biodynamic results on insulin release and blood concentrations indicate that oral GLP-1 could be an effective treatment in diabetes. The PYY results in combination with the GLP results could mean that oral PYY and oral GLP-1 could also be an effective treatment for other diseases such as obesity. We will seek to publish these results," said Dr. Christoph Beglinger of the University Hospital in Basel.

"We are very pleased to be working on the oral delivery of GLP-1 and PYY with a leading academic researcher such as Dr. Beglinger in the field of gastroenterology. The compounds GLP-1 and PYY are gastrointestinally produced hormones and GLP-1 is already an important compound in the treatment of diabetes as an injectable agent. Non-oral forms of these compounds are being explored in the treatment of obesity. We are looking forward in 2007 to initiating and completing a proof-of-concept efficacy study on the reduction of food intake using our oral incretin products with Dr. Beglinger," said Lewis H. Bender, President and CEO of Emisphere Technologies, Inc.

About GLP-1

Glucagon-l
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
2. Cobalis Reports Phase III Trial Results for PreHistin in Seasonal Allergic Rhinitis
3. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
4. Cytos Biotechnology Reports Results from Phase IIa Study with CYT003-QbG10 in Patients Suffering from Atopic Dermatitis
5. Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
6. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
7. Cytochroma Reports Positive Phase I Clinical Data for CTA018 Injection
8. Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension
9. Columbia Laboratories Reports Positive Results from Multi-dose Pharmacokinetic Study of Vaginally-administered Lidocaine
10. CytRx Reports Promising Data from Its Open-Label Extension Clinical Trial of Arimoclomol in ALS
11. Affymax Reports Phase 2 Clinical Dose Ranging Results of Once-Per-Month Hematide for the Treatment of Anemia
Post Your Comments:
(Date:7/10/2014)... 10, 2014  RESMED INC. (NYSE: RMD ) ... fiscal year ended June 30, 2014 results on Thursday, July ... A press release with ResMed,s results will be issued after ... a webcast to discuss operating results and future outlook. ... p.m. US Pacific Time and the live webcast of the ...
(Date:7/10/2014)... , July 10, 2014  Decision Resources ... surveyed infectious disease (ID) specialists are willing to ... Orbactiv (oritavancin) for use as OPAT, approximately two-thirds ... these agents to their hospital inpatients. However, our ... OPAT patients are initiated on OPAT following hospital ...
(Date:1/15/2014)... 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting ... China,s orthopedic instrument industry has ... size rising from 3.28 billion yuan in 2006 to ...
Breaking Medicine Technology:ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3
... 29, 2012 Keryx Biopharmaceuticals, Inc. (NASDAQ: ... development and commercialization of medically important pharmaceutical products for ... disease (the "Company"), today announced its results for the ... At December 31, 2011, the Company had cash, ...
... Feb. 29, 2012  Amgen (NASDAQ: AMGN ) ... Annual Healthcare Conference on Monday, March 5, 2012 at ... approximately 2:50 p.m. Eastern Standard Time.  Jonathan M. Peacock, ... will present. Live audio of the presentation can be ...
Cached Medicine Technology:Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2011 Financial Results 2Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2011 Financial Results 3Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2011 Financial Results 4Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2011 Financial Results 5
(Date:7/12/2014)... 12, 2014 Casinos in ... rising competition from international and online casinos. Revenue is ... the five years through 2014-15. Greater per capita gambling ... gaming services. Rises in discretionary income levels have also ... on non-essential items such as casino gambling services. Revenue ...
(Date:7/12/2014)... Pittsburgh, PA (PRWEB) July 12, 2014 "The ... so it’s uncomfortable and painful to wear shoes," said an ... a special sock that prevents this from happening. , He ... an effective way to prevent the second and big toes ... more endurance while wearing shoes. Ergonomic and easy to use, ...
(Date:7/12/2014)... Using and carrying around a catheter bag ... Ashland, Va., decided that there needed to be an ... conceive of our design," he said. , They then ... provides an inconspicuous way to use and carry a ... promotes comfort and peace of mind. Producible in design ...
(Date:7/12/2014)... CA (PRWEB) July 12, 2014 For those ... are bodies can readily absorb the nutrients in food. The ... particles that are small enough to be absorbed by human ... team, a lack of enzymes in regular food is the ... a product that was started by Michelle DelPresto, a mother ...
(Date:7/12/2014)... PA (PRWEB) July 12, 2014 Doylestown ... covering a variety of men’s health questions. Paddock ... specific to men, why women live longer than men, ... Men's Health Made Simple featured on Doylestown ... get a hernia at any age. If you notice ...
Breaking Medicine News(10 mins):Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:New Super Digestive Enzyme, DZ10, Supercharges The Digestion Process 2Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2
... Cancer Research Insitiute, UK suggests that women on tamoxifen have ... They report on a large scale trial of tamoxifen to ... to 65 years, from the UK, Australia, New Zealand and ... the women were considered as being at increased risk of ...
... effective delivery of drugs for a number of conditions. According to ... with the use of nasal sprays to treat allergies such as ... of delivering a drug, because it gets into the bloodstream fast ... fact, act quicker than the corresponding pill. Nasal sprays are already ...
... can control a stressful situation makes it easier on ... is potentially damaging to health because it increases blood ... responses may accumulate to increase the risk of heart ... stress is moderated by many psychological factors, such as ...
... that reduces the level of copper in the blood ... animals. Wilson's disease is a rare disorder where patients ... bodies. Researchers at the University of Texas, through research ... as tetrathiomolybdate (TM) that could fight cancer by lowering ...
... could be used to treat heart and lung disease. ... experiment in healthy young men,// the results of which ... and lung disease. ,They report that the ... hypertension (caused by conditions such as heart valve disease, ...
... in the American Journal of Clinical Nutrition it was observed ... the build up of plaque in the arteries that can ... can protect against the formation of plaque in the arteries. ... diagnosed with heart disease or who had suffered a heart ...
Cached Medicine News:
... easiest, most flexible meter for ... in hospitals. Accu-Chek Inform System ... It is the only Point ... allows for the entry and ...
... the NEXES Special Stains automated ... protocols to provide enhanced consistency ... silver stains. Proprietary kinetic technology, ... Vortex™ Mixing, assures high quality ...
... MTS and the University of Washington ... assessment online for the clinical lab ... training and continuing education include Safety, ... Microbiology. Competency Assessment tests feature high-resolution ...
... a nonprofit, physician-directed organization promoting quality ... care through programs of voluntary education, ... professionals in all sizes of medical ... accreditation, quality management services, consultation in ...
Medicine Products: