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Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery,of GLP-1 and PYY

- Study shows orally-delivered GLP-1 is able to stimulate insulin release

TARRYTOWN, N.Y., March 29, 2007 /PRNewswire-FirstCall/ -- Emisphere Technologies, Inc. reported today results of two clinical studies conducted in collaboration with Professor Christoph Beglinger, M.D. Division of Gastroenterology and Hepatology, University Hospital Basel in Basel, Switzerland. The objective of the study with glucagon-like peptide-1 (7-36 amide) (GLP-1) was to establish the initial pharmacological profile and the insulin releasing activity of increasing oral doses of GLP-1 in healthy volunteers. In addition, the pharmacokinetic effects of GLP-1 were investigated after intravenous administration. The objective of the study with peptide YY 3-36 (PYY) was to establish the PYY plasma concentrations following increasing oral doses of the peptide.

The results showed that Emisphere's eligen(R) technology can orally deliver the incretin hormones GLP-1 and PYY. The oral administration of both peptides induced a rapid and dose-dependent, statistically significant increase in plasma drug concentrations (p<0.05) at all doses tested versus placebo. Additionally, the orally delivered GLP-1 induced a statistically significant effect on insulin release in all healthy male volunteers (p<0.05) at all doses tested versus placebo. The Company expects these results to be published in a leading peer-reviewed scientific journal later this year.

GLP-1 was given orally to six healthy male subjects in a six way cross-over design. The treatment arms consisted of oral doses of GLP-1 (0.5, 1.0, 2.0 and 4.0 mg of drug) with Emisphere's delivery agent administered as a single tablet versus placebo. Only one dose was given per day. On a separate day, subjects received an intravenous infusion of GLP-1 (0.4 pMol/kg/min infused for 45 minutes). Blood samples were obtained for GLP-1 and insulin concentrations. The Cmax plasma concentration for
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