Navigation Links
Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery,of GLP-1 and PYY

- Study shows orally-delivered GLP-1 is able to stimulate insulin release

TARRYTOWN, N.Y., March 29, 2007 /PRNewswire-FirstCall/ -- Emisphere Technologies, Inc. reported today results of two clinical studies conducted in collaboration with Professor Christoph Beglinger, M.D. Division of Gastroenterology and Hepatology, University Hospital Basel in Basel, Switzerland. The objective of the study with glucagon-like peptide-1 (7-36 amide) (GLP-1) was to establish the initial pharmacological profile and the insulin releasing activity of increasing oral doses of GLP-1 in healthy volunteers. In addition, the pharmacokinetic effects of GLP-1 were investigated after intravenous administration. The objective of the study with peptide YY 3-36 (PYY) was to establish the PYY plasma concentrations following increasing oral doses of the peptide.

The results showed that Emisphere's eligen(R) technology can orally deliver the incretin hormones GLP-1 and PYY. The oral administration of both peptides induced a rapid and dose-dependent, statistically significant increase in plasma drug concentrations (p<0.05) at all doses tested versus placebo. Additionally, the orally delivered GLP-1 induced a statistically significant effect on insulin release in all healthy male volunteers (p<0.05) at all doses tested versus placebo. The Company expects these results to be published in a leading peer-reviewed scientific journal later this year.

GLP-1 was given orally to six healthy male subjects in a six way cross-over design. The treatment arms consisted of oral doses of GLP-1 (0.5, 1.0, 2.0 and 4.0 mg of drug) with Emisphere's delivery agent administered as a single tablet versus placebo. Only one dose was given per day. On a separate day, subjects received an intravenous infusion of GLP-1 (0.4 pMol/kg/min infused for 45 minutes). Blood samples were obtained for GLP-1 and insulin concentrations. The Cmax plasma concentration for
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
2. Cobalis Reports Phase III Trial Results for PreHistin in Seasonal Allergic Rhinitis
3. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
4. Cytos Biotechnology Reports Results from Phase IIa Study with CYT003-QbG10 in Patients Suffering from Atopic Dermatitis
5. Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
6. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
7. Cytochroma Reports Positive Phase I Clinical Data for CTA018 Injection
8. Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension
9. Columbia Laboratories Reports Positive Results from Multi-dose Pharmacokinetic Study of Vaginally-administered Lidocaine
10. CytRx Reports Promising Data from Its Open-Label Extension Clinical Trial of Arimoclomol in ALS
11. Affymax Reports Phase 2 Clinical Dose Ranging Results of Once-Per-Month Hematide for the Treatment of Anemia
Post Your Comments:
(Date:6/1/2015)... 2015 The nuclear imaging market is estimated ... CAGR of 12.08%. Nuclear medicine is the use of ... types of Nuclear imaging used commonly are PET and ... for nuclear medicine applications like nuclear cardiology procedures. However, ... global shortage of molybdenum-99 isotope which is in turn ...
(Date:6/1/2015)... PARK, Calif. , June 1, 2015 ... device company that is providing innovative evidence-based solutions for ... has commenced an underwritten public offering of its common ... Nevro and 2,459,175 shares to be sold by certain ... the underwriters a 30-day option to purchase up to ...
(Date:6/1/2015)... 1, 2015 NEOVIA ONCOLOGY Ltd. ... the development and commercialization of novel, multi-function drugs ... met with the U.S. Food and Drug Administration ... an Investigational New Drug (IND) application for its ... of the meeting, Neovia has clarified details of ...
Breaking Medicine Technology:North America Nuclear Imaging Market - Growth, Trends And Forecasts (2014 - 2019) 2North America Nuclear Imaging Market - Growth, Trends And Forecasts (2014 - 2019) 3Nevro Announces Proposed Public Offering of Common Stock 2Nevro Announces Proposed Public Offering of Common Stock 3Neovia Oncology Announces First IND Meeting 2
... and WILMINGTON, Del., Dec. 21 Eli Lilly and ... (Nasdaq: INCY ) announced today that they have ... for the development and commercialization of Incyte,s oral JAK1/JAK2 ... and autoimmune diseases. The lead compound, INCB28050, is currently ...
... , CARLSBAD, Calif., Dec. 21 Isis ... will receive a $10 million payment from OncoGenex Pharmaceuticals, Inc. ... license of OGX-011 to Teva Pharmaceutical Industries Ltd. ( TEVA). ... and OncoGenex that has completed a successful Phase 2 program ...
Cached Medicine Technology:Lilly and Incyte Announce Collaboration for Development and Commercialization of Oral Anti-Inflammatory and Autoimmune Therapies 2Lilly and Incyte Announce Collaboration for Development and Commercialization of Oral Anti-Inflammatory and Autoimmune Therapies 3Lilly and Incyte Announce Collaboration for Development and Commercialization of Oral Anti-Inflammatory and Autoimmune Therapies 4Lilly and Incyte Announce Collaboration for Development and Commercialization of Oral Anti-Inflammatory and Autoimmune Therapies 5Lilly and Incyte Announce Collaboration for Development and Commercialization of Oral Anti-Inflammatory and Autoimmune Therapies 6Isis Pharmaceuticals to Receive $10 Million From OncoGenex' License of OGX-011 to Teva 2Isis Pharmaceuticals to Receive $10 Million From OncoGenex' License of OGX-011 to Teva 3
(Date:6/2/2015)... (PRWEB) June 02, 2015 Each year, ... Insiders’ Choice Beauty Awards. This year, the organization’s members ... the winner of the QVC® Beauty Quest Award at ... results-driven Micro Emulsion (ME) Technology and 2-in-1 approach to ... Also noting the brand’s loyal consumer and professional fan ...
(Date:6/2/2015)... 2015 SB 277 (CA Legislature, bit.ly/1Q0P8OY) ... to attend public or private school. SB277 cleared three ... the Appropriations Committee (Sacramento Bee, May 11, 2015, bit.ly/1Gh9jU7). ... , “We believe that this bill affects the ... than it will (the) affect public health of California.. ...
(Date:6/1/2015)... NY (PRWEB) June 02, 2015 ... Miriam Wirski as a 2015-2016 inductee into ... recognized with this prestigious distinction for leadership in business. ... professional women, boasting more than 700,000 members and over ... Miriam with this prestigious honor,” said NAPW President Star ...
(Date:6/1/2015)... June 02, 2015 The National ... Willey as a 2015-2016 inductee into its VIP ... with this prestigious distinction for leadership in safety, environment, ... networking organization exclusively for professional women, boasting more than ... "I’m pleased to present Lourinda with this important honor,” ...
(Date:6/1/2015)... The National Association of Professional Women ... (C), First Sergeant A Co., 15BSB , as a ... Circle. She is recognized with this prestigious distinction for ... networking organization exclusively for professional women, boasting more than ... “I'm pleased to recognize Sergeant Cornett with this important ...
Breaking Medicine News(10 mins):Health News:Scalisi Skincare Wins Coveted CEW QVC Beauty Quest Award for Innovative and Patented Formulation 2Health News:A Voice For Choice Releases A Statement As SB277 Is Referred To Single Assembly Committee And Bypasses Education and Judicial Scrutiny 2Health News:National Association of Professional Women Inducts Miriam Wirski, Holistic Life Coach, Into its VIP Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Lourinda Willey, Owner and Principal of Lourinda R. Willey LLC, Into its VIP Professional Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Lenita F. Cornett, First Sergeant of the US Military, Into its VIP Professional Woman of the Year Circle 2
... RIVERSIDE, California and NUREMBERG, Germany, June ... United States Food and Drug,Administration (FDA) has given 510k ... the Ziehm Vision(R) RFD, for marketing and,sales within the ... and interventional radiology, the Ziehm Vision RFD,mobile C-arm combines ...
... M.A.Z.E. ... is dedicated to helping parents save money and the giveaway is another chance for parents ... ... education with M.A.Z.E. Cord Blood Laboratories. M.A.Z.E. is offering a drawing to win a ...
... LONDON, June 10 ThirdForce, the UK,s leading,e-learning ... one of,the most respected care home companies in the UK, ... for Life,e-learning to enhance Barchester,s quality provision of care and ... a key component to the success of the,Barchester business; a ...
... percent of the 5.5 billion kilograms of toxic pollutant ... can be traced to just 30 substances from 15 ... according to the latest tri-national pollution report from the ... 2005, released today,represents the most complete picture of pollution ...
... difference to Ontario,s community mental health system? According to ... the answer is yes. Ontarians now have access to ... also highlights the system,s limited resources to serve all ... for Addiction and Mental Health (CAMH),s Dr. Paula Goering, ...
... New Tissue Dissection System Used by Italian Surgeons in Oncology ... PALO ALTO, Calif., June 10 PEAK Surgical, Inc., today ... surgeons in the European Union, where the innovative tissue dissection ... , Dr. Raul Pellini and Prof. Giuseppe Spriano, ear, nose ...
Cached Medicine News:Health News:SVS 2009: Ziehm Imaging Sets a New Standard in Mobile Imaging With the Ziehm Vision RFD 2Health News:SVS 2009: Ziehm Imaging Sets a New Standard in Mobile Imaging With the Ziehm Vision RFD 3Health News:M.A.Z.E. Cord Blood Laboratories Offers Expectant Parents The Chance To Win A $500 Savings Bond 2Health News:Barchester Healthcare Gains Skills for Life With ThirdForce 2Health News:Barchester Healthcare Gains Skills for Life With ThirdForce 3Health News:Latest trinational report presents most complete picture of North American industrial pollution 2Health News:Latest trinational report presents most complete picture of North American industrial pollution 3Health News:Evaluation shows $167 million investment improves community mental health system, but many still in need 2Health News:PEAK Surgical Announces First Use of PEAK PlasmaBlade(TM) in Europe 2Health News:PEAK Surgical Announces First Use of PEAK PlasmaBlade(TM) in Europe 3Health News:PEAK Surgical Announces First Use of PEAK PlasmaBlade(TM) in Europe 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: