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Eloxatin (oxaliplatin injection)-Based Chemotherapy Sets New,Treatment Benchmark in Patients With Metastatic Colorectal Cancer

of all the results reported. In comparison, the chance of living five years was 5.4% among patients treated with Eloxatin(R) plus irinotecan (IROX) (p=.016) and 3.8% (p<.001) among patients treated with the combination of 5-FU/LV and irinotecan (IFL).

FOLFOX4 slowed the progression of the disease compared to IROX and IFL. The median TTP was significantly longer among FOLFOX4-treated patients at 9.2 months compared to 6.5 months with IROX (p=<.001) and 6 months with IFL (p=<.001). FOLFOX4 patients were significantly more likely to experience any grade 3 or greater side effects (odds ratio of 1.65, p<.001) and were lower in men than in women (OR 0.63, p<0.001). The most common side effects were peripheral sensory neuropathy, fatigue, neutropenia, nausea, vomiting, and diarrhea.

"Our five-year overall survival results with first-line FOLFOX4 set a new benchmark for treating metastatic colorectal cancer," said lead investigator Richard Goldberg, MD, University of North Carolina School of Medicine, Chapel Hill, NC. "Adding Eloxatin(R) to standard chemotherapy significantly prolonged survival for these patients and also delayed disease progression."

Treatment with FOLFOX4 Predicts Important Benefits

Receiving FOLFOX4 was found to be the most powerful prognostic factor for predicting overall survival as well as time to progression. Those factors that were predictive of a worse outcome were: higher baseline performance status, neutrophil count, and alkaline phosphatase, as well as a greater number of disease sites. While being 70 years or older was associated with poorer survival, it was not predictive of time to progression, response rate or grade 3 or greater toxicity.

For more information about Eloxatin(R) or for full prescribing information, including BOXED WARNING, visit www.eloxatin.com.

About Colorectal Cancer

Strides have been made in the management of colorectal
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