( n the United States alone. While there ...)Elixir Pharmaceuticals Announces Clinical Data at American Diabetes,Association Conference Highlighting Ability of Glufast to Maintain,Glycemic Control in Patients with Type 2 Diabetes,Health

About Elixir Pharmaceuticals

Elixir is a Cambridge, MA-based biopharmaceutical company focused on developing and commercializing drugs to treat and prevent metabolic disease, prevent age-related diseases, ultimately extending the quality and length of human life.

In addition to the Glufast program, the Company has leveraged its knowledge of ghrelin biology and pharmacology and is advancing both ghrelin antagonists and agonists.

The Company's ghrelin antagonist, EX-1350, is a proprietary, small molecule designed to bind to the human ghrelin receptor. Elixir has demonstrated EX-1350 reduces body weight by 10 percent at 28-56 days without significant decreases in food intake in an animal model made insulin resistant and obese after three months on a 60 percent fat diet. The majority of the weight loss is observed in white adipose tissue, with sparing of skeletal muscle. Furthermore, glucose surge and disposal was found to be improved significantly in EX-1350-treated mice compared to vehicle, and the insulin required to dispose of the glucose was reduced dramatically, indicating improved insulin sensitivity.

In April 2005, Elixir licensed a small molecule ghrelin agonist (designated EX-1314) from Bristol-Myers Squibb Company. EX-1314 binds selectively to the ghrelin receptor and mimics the body's naturally occurring ghrelin. In doing so this novel, orally available agent is capable of stimulating appetite, gastric motility, and the release of growth hormone. Elixir is currently in IND-enabling studies with EX-1314 targeting a variety of therapeutic indications.

Elixir also has developed expertise and a broad IP portfolio of more than twenty patents and patent applications related to the Sirtuin class of proteins, including small molecular weight SIRT1 activators and in
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