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Efficacy and Safety Profile of Basilea's Alitretinoin for Severe,Refractory Chronic Hand Eczema Confirmed by Data Shown at European,Dermatology Congress

after single and repeated oral dosing of 5, 10 and 20mg in healthy volunteers. Schmitt-Hoffman A, Roos B, Brown T, Maares J.

P289 / Alitretinoin (BAL4079; 9-cis retinoic acid): Mass-balance excretion study of oral alitretinoin in healthy volunteers. Schmitt-Hoffman A, Roos B, Brown T, van Lier JJ.

P290 / Alitretinoin (BAL4079: 9-cis retinoic acid): Low levels in seminal fluid after repeated oral dosing. Schmitt-Hoffman A, Roos B, Brown T, Meyer I.

About Chronic Hand Eczema (CHE) Hand eczema is a common skin disease and is often chronic and relapsing. It is estimated to affect up to 10% of the general population. The more severe, chronic form of the condition is thought to affect up to 7% of these patients, many of whom do not respond, or no longer respond to topical corticosteroids. Basilea estimates there are at least one million patients in Europe and North America with severe refractory CHE for which currently no approved, effective pharmaceutical treatment is available.

About Alitretinoin Alitretinoin is an investigational drug being developed in Phase III clinical trials by Basilea as a novel treatment for severe refractory Chronic Hand Eczema (CHE), a complex disease for which no effective treatment options are currently available. Alitretinoin has been shown to be effective in clinical studies in patients with severe refractory CHE. Alitretinoin is a teratogen and therefore pregnancy prevention measures must be in place for all women of child-bearing potential who receive alitretinoin. Within days after discontinuation of therapy, alitretinoin levels return to endogenous levels. In clinical studies the post-treatment contraceptive period was four weeks.

About Basilea Basilea Pharmaceutica Ltd. is an independent biopharmaceutical company headquartered in Basel, Switzerland, and listed on the SWX Swiss Exchange (SWX:BSLN). Basilea's fully integrated research and development operations are currently focused on new antibacteria
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