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EPIX Pharmaceuticals Announces Statistically Significant Results in,Cognitive Function from Phase 1b Clinical Trial of Novel 5-HT6 Drug,Candidate

ne month period than subjects on placebo.

"We are very pleased with the tolerability and pro-cognitive effects observed in this Phase 1b clinical trial of PRX-07034," said Michael G. Kauffman, M.D., Ph.D., chief executive officer, EPIX Pharmaceuticals. "These data support plans to initiate further clinical trials to evaluate the efficacy of PRX-07034 in obesity, cognitive impairment associated conditions, or both. We will continue to evaluate the data and provide an update on our plans in the coming months."

Dr. Kauffman added, "We are continuing to advance our pipeline of proprietary drug candidates and look forward to our next milestone - obtaining the results from our ongoing Phase 2a trial of PRX-08066 in pulmonary hypertension associated with chronic obstructive pulmonary disease, which we expect mid-year."

These results were announced this morning in an oral presentation by Kimberley S. Gannon, Ph.D., senior director of biology for EPIX, at the "ALZHEIMER'S DISEASE: From Molecular Mechanisms to Drug Discovery" conference in Punta Cana, Dominican Republic.

About PRX-07034

PRX-07034 is a novel, highly selective, small-molecule antagonist of a specific G-protein coupled receptor (GPCR) known as 5-HT6, which was discovered by EPIX using its proprietary in silico drug discovery platform. PRX-07034 has shown cognitive-enhancing properties in preclinical animal models of memory impairment, as well as reductions of both food intake and body weight in several preclinical animal models of obesity. The human 5-HT6 receptor is found predominantly in the central nervous system with little or no expression in peripheral tissues, which may result in fewer peripheral side effects.

About CogScreen(TM)

CogScreen(TM) is a widely used tool that encompasses a battery of tests originally designed to assess memory and cognition in normal individuals with demonstrated utility in
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