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Discovery's KL-4 Surfactant Technology Demonstrates Novel,Anti-Inflammatory Properties

Discovery's KL-4 Surfactant Technology Demonstrates Novel Anti-Inflammatory Properties

New Surfaxin Data Presented At the 2007 Pediatric Academic Societies Annual Meeting

WARRINGTON, Pa., May 9, 2007 (PRIME NEWSWIRE) -- Discovery Laboratories, Inc. (Nasdaq:DSCO) announced that new data supporting the anti-inflammatory properties of its novel KL-4 surfactant (lucinactant) replacement technology were presented yesterday at the Pediatric Academic Societies Annual Meeting in Toronto, Canada. The presentations included the results from two studies that demonstrate Surfaxin(r) (lucinactant administered as an intratracheal suspension) has the potential to reduce lung inflammation. The Pediatric Academic Societies annual meeting is internationally recognized as the largest, most relevant medical meeting dedicated to pediatric critical care research.

The following studies were presented:

* Surfaxin (KL-4 surfactant) Protects Human Airway Epithelium from Hyperoxia: Yan Zhu, Thomas L. Miller, Aaron C. Chidekel, and Thomas H. Shaffer. The objective was to assess the impact of multiple surfactants, including Surfaxin, on hyperoxic induced lung injury in an in- vitro cell-culture model. The authors concluded that Surfaxin reduced the inflammatory response and therefore improved cell survival and function compared with both a saline control as well as Survanta(r) (beractant), an animal-derived surfactant and the most prescribed surfactant in the United States.

* Surfaxin (KL-4 Surfactant) is Associated with a Reduction in Bone Morphogenetic Protein (BMP) Gene Expression in a Cell Culture-Based Assay of Lung Inflammation: De-Ann M. Pillers, M.D., Ph.D., Paul Nkadi, M.D., Jiaqing Pang, M.S. and T. Allen Merritt, M.D. The objective was to determine the impact of Surfaxin on cytokine-driven lung inflammation and focus specifically on the transforming growth factor-beta (TGF-beta) superfamily. Members o
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